Y964_NEIMB
ID Y964_NEIMB Reviewed; 758 AA.
AC Q9JZN9;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Probable TonB-dependent receptor NMB0964;
DE Flags: Precursor;
GN OrderedLocusNames=NMB0964;
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58;
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17038831; DOI=10.4161/hv.1.2.1651;
RA Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.;
RT "Characterization of the protein content of a meningococcal outer membrane
RT vesicle vaccine by polyacrylamide gel electrophoresis and mass
RT spectrometry.";
RL Hum. Vaccin. 1:80-84(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=NZ98/254 / Serogroup B;
RX PubMed=16645985; DOI=10.1002/pmic.200500821;
RA Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.;
RT "Proteomic analysis of a meningococcal outer membrane vesicle vaccine
RT prepared from the group B strain NZ98/254.";
RL Proteomics 6:3400-3413(2006).
CC -!- FUNCTION: Probable receptor, TonB-dependent. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC -!- MISCELLANEOUS: Present in outer membrane vesicle formulations which are
CC used as vaccines in human.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; AE002098; AAF62323.1; -; Genomic_DNA.
DR RefSeq; NP_274002.1; NC_003112.2.
DR RefSeq; WP_002244095.1; NC_003112.2.
DR PDB; 4RDR; X-ray; 2.47 A; A=25-758.
DR PDB; 4RDT; X-ray; 3.20 A; A/B=25-758.
DR PDB; 4RVW; X-ray; 4.48 A; A=25-758.
DR PDBsum; 4RDR; -.
DR PDBsum; 4RDT; -.
DR PDBsum; 4RVW; -.
DR AlphaFoldDB; Q9JZN9; -.
DR SMR; Q9JZN9; -.
DR STRING; 122586.NMB0964; -.
DR TCDB; 1.B.14.2.9; the outer membrane receptor (omr) family.
DR PaxDb; Q9JZN9; -.
DR EnsemblBacteria; AAF62323; AAF62323; NMB0964.
DR KEGG; nme:NMB0964; -.
DR PATRIC; fig|122586.8.peg.1222; -.
DR HOGENOM; CLU_008287_10_1_4; -.
DR OMA; NHREEWS; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Membrane; Receptor; Reference proteome;
KW Signal; TonB box; Transmembrane; Transmembrane beta strand.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..758
FT /note="Probable TonB-dependent receptor NMB0964"
FT /id="PRO_0000349888"
FT MOTIF 741..758
FT /note="TonB C-terminal box"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 63..66
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 73..77
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 83..88
FT /evidence="ECO:0007829|PDB:4RDR"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 92..97
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 102..104
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 105..109
FT /evidence="ECO:0007829|PDB:4RDR"
FT TURN 118..120
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 130..132
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 133..139
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 142..146
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 155..163
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 169..171
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 172..181
FT /evidence="ECO:0007829|PDB:4RDR"
FT TURN 182..184
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 187..196
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 198..212
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 214..216
FT /evidence="ECO:0007829|PDB:4RDT"
FT STRAND 218..220
FT /evidence="ECO:0007829|PDB:4RDT"
FT STRAND 224..226
FT /evidence="ECO:0007829|PDB:4RDT"
FT STRAND 231..242
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 245..261
FT /evidence="ECO:0007829|PDB:4RDR"
FT TURN 268..271
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 272..275
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 279..284
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 287..290
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 292..294
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 297..299
FT /evidence="ECO:0007829|PDB:4RDR"
FT TURN 300..302
FT /evidence="ECO:0007829|PDB:4RDT"
FT STRAND 306..309
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 326..342
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 348..366
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 369..387
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 390..410
FT /evidence="ECO:0007829|PDB:4RDR"
FT TURN 414..416
FT /evidence="ECO:0007829|PDB:4RDT"
FT STRAND 420..439
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 442..456
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 461..468
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 480..494
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 496..510
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 514..518
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 520..523
FT /evidence="ECO:0007829|PDB:4RDR"
FT HELIX 524..526
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 528..531
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 539..552
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 555..574
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 576..580
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 591..614
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 617..632
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 663..673
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 676..685
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 701..713
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 715..726
FT /evidence="ECO:0007829|PDB:4RDR"
FT TURN 739..742
FT /evidence="ECO:0007829|PDB:4RDR"
FT STRAND 749..758
FT /evidence="ECO:0007829|PDB:4RDR"
SQ SEQUENCE 758 AA; 85120 MW; 6BA342986968640B CRC64;
MAQTTLKPIV LSILLINTPL LAQAHETEQS VDLETVSVVG KSRPRATSGL LHTSTASDKI
ISGDTLRQKA VNLGDALDGV PGIHASQYGG GASAPVIRGQ TGRRIKVLNH HGETGDMADF
SPDHAIMVDT ALSQQVEILR GPVTLLYSSG NVAGLVDVAD GKIPEKMPEN GVSGELGLRL
SSGNLEKLTS GGINIGLGKN FVLHTEGLYR KSGDYAVPRY RNLKRLPDSH ADSQTGSIGL
SWVGEKGFIG VAYSDRRDQY GLPAHSHEYD DCHADIIWQK SLINKRYLQL YPHLLTEEDI
DYDNPGLSCG FHDDDNAHAH THSGRPWIDL RNKRYELRAE WKQPFPGFEA LRVHLNRNDY
RHDEKAGDAV ENFFNNQTQN ARIELRHQPI GRLKGSWGVQ YLQQKSSALS AISEAVKQPM
LLDNKVQHYS FFGVEQANWD NFTLEGGVRV EKQKASIQYD KALIDRENYY NHPLPDLGAH
RQTARSFALS GNWYFTPQHK LSLTASHQER LPSTQELYAH GKHVATNTFE VGNKHLNKER
SNNIELALGY EGDRWQYNLA LYRNRFGNYI YAQTLNDGRG PKSIEDDSEM KLVRYNQSGA
DFYGAEGEIY FKPTPRYRIG VSGDYVRGRL KNLPSLPGRE DAYGNRPFIA QDDQNAPRVP
AARLGFHLKA SLTDRIDANL DYYRVFAQNK LARYETRTPG HHMLNLGANY RRNTRYGEWN
WYVKADNLLN QSVYAHSSFL SDTPQMGRSF TGGVNVKF
