Y968_MYCTU
ID Y968_MYCTU Reviewed; 98 AA.
AC P9WKL9; L0T889; P64779; P71542;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 31.
DE RecName: Full=Uncharacterized protein Rv0968;
GN OrderedLocusNames=Rv0968; ORFNames=MTCY10D7.06c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=16586367; DOI=10.1086/502631;
RA Jain S.K., Paul-Satyaseela M., Lamichhane G., Kim K.S., Bishai W.R.;
RT "Mycobacterium tuberculosis invasion and traversal across an in vitro human
RT blood-brain barrier as a pathogenic mechanism for central nervous system
RT tuberculosis.";
RL J. Infect. Dis. 193:1287-1295(2006).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- INDUCTION: Highly up-regulated during the early stages of invasion of
CC the human blood-brain barrier. {ECO:0000269|PubMed:16586367}.
CC -!- SIMILARITY: To M.tuberculosis Rv1991c and Rv3269. {ECO:0000305}.
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DR EMBL; AL123456; CCP43717.1; -; Genomic_DNA.
DR PIR; F70718; F70718.
DR RefSeq; NP_215483.1; NC_000962.3.
DR RefSeq; WP_003404939.1; NZ_NVQJ01000001.1.
DR AlphaFoldDB; P9WKL9; -.
DR SMR; P9WKL9; -.
DR STRING; 83332.Rv0968; -.
DR PaxDb; P9WKL9; -.
DR DNASU; 885052; -.
DR GeneID; 885052; -.
DR KEGG; mtu:Rv0968; -.
DR TubercuList; Rv0968; -.
DR eggNOG; ENOG5030ARM; Bacteria.
DR OMA; MTLWHGL; -.
DR PhylomeDB; P9WKL9; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR InterPro; IPR009963; DUF1490.
DR Pfam; PF07371; DUF1490; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..98
FT /note="Uncharacterized protein Rv0968"
FT /id="PRO_0000103765"
FT REGION 77..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 98 AA; 10264 MW; 3F13A55C8EF0DA47 CRC64;
MVWHGFLAKA VPTVVTGAVG VAAYEALRKM VVKAPLRAAT VSVAAWGIRL AREAERKAGE
SAEQARLMFA DVLAEASERA GEEVPPLAVA GSDDGHDH