ID   Y970_MYCTU              Reviewed;         210 AA.
AC   P9WKL7; L0T6Y4; P64781; P71541;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Uncharacterized protein Rv0970;
GN   OrderedLocusNames=Rv0970; ORFNames=MTCY10D7.04c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16586367; DOI=10.1086/502631;
RA   Jain S.K., Paul-Satyaseela M., Lamichhane G., Kim K.S., Bishai W.R.;
RT   "Mycobacterium tuberculosis invasion and traversal across an in vitro human
RT   blood-brain barrier as a pathogenic mechanism for central nervous system
RT   tuberculosis.";
RL   J. Infect. Dis. 193:1287-1295(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Highly up-regulated during the early stages of invasion of
CC       the human blood-brain barrier. {ECO:0000269|PubMed:16586367}.
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DR   EMBL; AL123456; CCP43719.1; -; Genomic_DNA.
DR   PIR; H70718; H70718.
DR   RefSeq; NP_215485.1; NC_000962.3.
DR   RefSeq; WP_003898666.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WKL7; -.
DR   STRING; 83332.Rv0970; -.
DR   PaxDb; P9WKL7; -.
DR   DNASU; 885242; -.
DR   GeneID; 885242; -.
DR   KEGG; mtu:Rv0970; -.
DR   TubercuList; Rv0970; -.
DR   eggNOG; ENOG50334C0; Bacteria.
DR   OMA; TSASPIW; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR033458; DUF5134.
DR   Pfam; PF17197; DUF5134; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..210
FT                   /note="Uncharacterized protein Rv0970"
FT                   /id="PRO_0000103767"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  22887 MW;  D4ED4FF6CC098F24 CRC64;
     MIHDLMLRWV VTGLFVLTAA ECGLAIIAKR RPWTLIVNHG LHFAMAVAMA VMAWPWGARV
     PTTGPAVFFL LAAVWFGATA VVAVRGTATR GLYGYHGLMM LATAWMYAAM NPRLLPVRSC
     TEYATEPDGS MPAMDMTAMN MPPNSGSPIW FSAVNWIGTV GFAVAAVFWA CRFVMERRQE
     ATQSRLPGSI GQAMMAAGMA MLFFAMLFPV