Y9719_DICDI
ID Y9719_DICDI Reviewed; 942 AA.
AC Q54WD7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Probable serine/threonine-protein kinase DDB_G0279719;
DE EC=2.7.11.1;
GN ORFNames=DDB_G0279719;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- INDUCTION: Down-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AAFI02000032; EAL67634.1; -; Genomic_DNA.
DR RefSeq; XP_641616.1; XM_636524.1.
DR AlphaFoldDB; Q54WD7; -.
DR SMR; Q54WD7; -.
DR STRING; 44689.DDB0216331; -.
DR PaxDb; Q54WD7; -.
DR PRIDE; Q54WD7; -.
DR EnsemblProtists; EAL67634; EAL67634; DDB_G0279719.
DR GeneID; 8622194; -.
DR KEGG; ddi:DDB_G0279719; -.
DR dictyBase; DDB_G0279719; -.
DR eggNOG; KOG0589; Eukaryota.
DR HOGENOM; CLU_311785_0_0_1; -.
DR InParanoid; Q54WD7; -.
DR OMA; IEWAEHQ; -.
DR PRO; PR:Q54WD7; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..942
FT /note="Probable serine/threonine-protein kinase
FT DDB_G0279719"
FT /id="PRO_0000362069"
FT DOMAIN 4..617
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 109..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 675..703
FT /evidence="ECO:0000255"
FT ACT_SITE 487
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 10..18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 942 AA; 105742 MW; ACD5AA33B53B4746 CRC64;
MNKYEVVKLI GVGGEAKALL VKRINSDKLY VMKQRMFFLL EEANEGLCEA MSLAKIQSPY
IVRFEEVFLD NNSNMFSLCI VMEYCEGGDL MDNLFKRISD SFLKNSGLNN NQNNNNNNNN
NLNSIVNNNI LNNNKNSKQS TTNTNSSGSN SSIASNTTNN NNNNNNINNN NNLKAYENFF
SKYVPSETLK GVNQLVEPNC NKDNNKPIEI TTTDSPRIII NDNESTNNLN SQSDQILQFS
ISSESSSFSN NDLINSPNSN DSNLHQSSSN SSICGDYSSP PNLEKISSPG TSTPYQKGSN
GNTVNIRCSD IVVEAVSPIK TESIGCQIRS TTSPCTSGPT SPQMIPLNIV EQPPQSTSTS
KTDSSPTGAD VKKTKMTWWK TYKSSKKDKK QTICSNACES FSNSTFFNDP SSHSQPQHQQ
LHSSPQQLPQ SPRLKPNIES SLNINGNNNN NNCSTLLKLP RKLFYTWIYQ ICLGVQSIHK
NHLVHLDLKS ENIFLSESQK IKIGDFGLAK KYENSMSGVA GTYYYLSPEI LLNKNYSRPA
DIFSLGCIFY EMYTLNLLPL TKRSFGQELI EGKFDRKAFK QEFDDSDEPI ADLILDMLNL
DQNLRPTIDL ILQNKLFERI SDINSSFNNL LNIVNNTGSS ITNSKSNSSN NLNNSNSNND
IINNNNNNNS SNNINNNNIV NLNNSYNNKQ DKCEQRNKSL NQNGFLSTSS MGSISSSFNE
HEFVRRQLEK NDLDAAADVL CEAFKEEPRF QFVSGATSDN LETKNKSIEL GQTIRKSFFT
MCVRLMFDNK FMLWGCFDYE NKLIAVACWS TPGKSGAPPM TQLIVKILSM LPKFGFRTMK
RIGKIMSNID KAMKNHDSKL DVYYLPYIGV SKEYRDLGVG QYLLKPVIEW AEHQRKTVKA
VVFSQKQINF FSKLGLSVGH TEKITNLKGI NSIYVMSKNS QY