ID   Y972_PYRFU              Reviewed;         350 AA.
AC   Q51798;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=UPF0219 protein PF0972 {ECO:0000255|HAMAP-Rule:MF_01409};
GN   OrderedLocusNames=PF0972;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=8550425; DOI=10.1128/jb.178.1.248-257.1996;
RA   Kletzin A., Adams M.W.W.;
RT   "Molecular and phylogenetic characterization of pyruvate and 2-
RT   ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and
RT   pyruvate ferredoxin oxidoreductase from Thermotoga maritima.";
RL   J. Bacteriol. 178:248-257(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. UPF0219 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01409}.
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DR   EMBL; X85250; CAA59499.1; -; Genomic_DNA.
DR   EMBL; AE009950; AAL81096.1; -; Genomic_DNA.
DR   PIR; T45082; T45082.
DR   RefSeq; WP_011012109.1; NC_018092.1.
DR   AlphaFoldDB; Q51798; -.
DR   SMR; Q51798; -.
DR   STRING; 186497.PF0972; -.
DR   PRIDE; Q51798; -.
DR   EnsemblBacteria; AAL81096; AAL81096; PF0972.
DR   GeneID; 41712784; -.
DR   KEGG; pfu:PF0972; -.
DR   PATRIC; fig|186497.12.peg.1031; -.
DR   eggNOG; arCOG01767; Archaea.
DR   HOGENOM; CLU_039592_7_0_2; -.
DR   OMA; YAKHKGK; -.
DR   OrthoDB; 12601at2157; -.
DR   PhylomeDB; Q51798; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 1.
DR   HAMAP; MF_01409; UPF0219; 1.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004656; FabH-rel.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; SSF53901; 1.
DR   TIGRFAMs; TIGR00748; HMG_CoA_syn_Arc; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..350
FT                   /note="UPF0219 protein PF0972"
FT                   /id="PRO_0000057622"
SQ   SEQUENCE   350 AA;  38201 MW;  0FE759454C3A9455 CRC64;
     MRKVMKPMKD VGIVGYGAYV PMYRIRNEEI GRVWGVSSFP IEEKAVPGLD EDAITIGIEA
     ARNALKRAKI DPQKIRAIWF GTESKPYAVK PSATIIAEAI GATPDLEAAD FEFACKAGTE
     ALQAAIGFVG SGMAEYAMAI GADTAQGRPG DHLEFTAGAG GAAFIVGEKS NESVAYFEGS
     YSYVTDTPDF WRRQHEHYPR HGNRFTGEPA YFHHIINAAK TLMEELGLKP SDFDYAVFHQ
     PNVKFPLTVA KILGIPKEKV LPGLLTGRIG NTYSGATMVG VSAVLDIAKP GDRILWVSFG
     SGAGSNAFSI VVQDAIEEKR DLAPKVEDYV KRRKVIDYAL YAKARRKYIL