ID   Y9745_DICDI             Reviewed;         410 AA.
AC   Q54WD3;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0279745;
GN   ORFNames=DDB_G0279745;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000032; EAL67552.1; -; Genomic_DNA.
DR   RefSeq; XP_641525.1; XM_636433.1.
DR   AlphaFoldDB; Q54WD3; -.
DR   PaxDb; Q54WD3; -.
DR   EnsemblProtists; EAL67552; EAL67552; DDB_G0279745.
DR   GeneID; 8622198; -.
DR   KEGG; ddi:DDB_G0279745; -.
DR   dictyBase; DDB_G0279745; -.
DR   HOGENOM; CLU_671620_0_0_1; -.
DR   InParanoid; Q54WD3; -.
DR   PhylomeDB; Q54WD3; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54WD3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR024957; Cep57_MT-bd_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF06657; Cep57_MT_bd; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..410
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0279745"
FT                   /id="PRO_0000393771"
FT   ZN_FING         27..67
FT                   /note="RING-type; degenerate"
FT   ZN_FING         81..154
FT                   /note="TRAF-type 1"
FT   ZN_FING         154..213
FT                   /note="TRAF-type 2"
FT   COILED          216..284
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   410 AA;  47122 MW;  C7188CE9E1012192 CRC64;
     MVRNSEITLE QIFKEGRINL ENDDYNCVIC SFPLFDGLQC KRGHGACKSC WEKIIGENGK
     KECHSCRISI KSLDDLSKNL YLEKEIFKQK VACLNNGREK FGNTLVIKSD GGCKRQDIPI
     EKLLHHIKNE CGYLLIDCKY SRDCKYYKQI SLEQHQNECQ FMSIHCPALC GKKDSRMNIN
     KHLETPNSCK PLISINNSNN SNGNGNGIDD ESIIKLSNSI VEIQKSYQNQ IKKIKENSES
     EIAALKDSLY YSKSRIKNLE DEVEELKDRF STLESMINKL DDSATSRSGT ILINGWKMKL
     KSLDVGHSIV EEQFYIGTNR FYIRIYPFGD SYDNQGYVTV KLGRIDGEEY HLDIGLKVSI
     KGFDNKKKVL LSYYPGDIAH NIDQLVETWE TSKEFKMILH FKVDLKPKIK