Y9776_DROME
ID Y9776_DROME Reviewed; 1260 AA.
AC Q9V468; Q7JRP8; Q8I092;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger matrin-type protein CG9776;
GN ORFNames=CG9776;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA Harvey D.A.;
RT "A Drosophila complementary DNA resource.";
RL Science 287:2222-2224(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335; THR-338 AND SER-1197,
RP AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-697; THR-700; SER-1228 AND
RP SER-1232, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9V468-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9V468-2; Sequence=VSP_037206, VSP_037207, VSP_037208;
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DR EMBL; AE014297; AAF52146.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13304.3; -; Genomic_DNA.
DR EMBL; AF160940; AAD46880.1; -; mRNA.
DR EMBL; BT001348; AAN71103.1; -; mRNA.
DR RefSeq; NP_649455.1; NM_141198.4. [Q9V468-1]
DR RefSeq; NP_730813.3; NM_164339.4. [Q9V468-2]
DR AlphaFoldDB; Q9V468; -.
DR SMR; Q9V468; -.
DR BioGRID; 65767; 21.
DR IntAct; Q9V468; 16.
DR STRING; 7227.FBpp0078595; -.
DR iPTMnet; Q9V468; -.
DR PaxDb; Q9V468; -.
DR PRIDE; Q9V468; -.
DR DNASU; 40546; -.
DR EnsemblMetazoa; FBtr0078955; FBpp0078595; FBgn0027866. [Q9V468-1]
DR EnsemblMetazoa; FBtr0078956; FBpp0078596; FBgn0027866. [Q9V468-2]
DR GeneID; 40546; -.
DR KEGG; dme:Dmel_CG9776; -.
DR UCSC; CG9776-RA; d. melanogaster. [Q9V468-1]
DR UCSC; CG9776-RB; d. melanogaster.
DR FlyBase; FBgn0027866; CG9776.
DR VEuPathDB; VectorBase:FBgn0027866; -.
DR eggNOG; ENOG502R1ZF; Eukaryota.
DR GeneTree; ENSGT00390000000614; -.
DR HOGENOM; CLU_006889_0_0_1; -.
DR InParanoid; Q9V468; -.
DR OMA; IDHDPFP; -.
DR PhylomeDB; Q9V468; -.
DR BioGRID-ORCS; 40546; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 40546; -.
DR PRO; PR:Q9V468; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0027866; Expressed in eye disc (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q9V468; baseline and differential.
DR Genevisible; Q9V468; DM.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1260
FT /note="Zinc finger matrin-type protein CG9776"
FT /id="PRO_0000372852"
FT ZN_FING 546..576
FT /note="Matrin-type"
FT REGION 1..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 285..366
FT /evidence="ECO:0000255"
FT COMPBIAS 64..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..143
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..640
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..721
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..869
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1063
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 338
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 697
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 700
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1197
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 1228
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1232
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 1..574
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_037206"
FT VAR_SEQ 575
FT /note="Q -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_037207"
FT VAR_SEQ 1258..1260
FT /note="YAL -> CM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_037208"
SQ SEQUENCE 1260 AA; 140295 MW; 098296D9FEA695CA CRC64;
MDEDSATIQL GDRRLGNAVD HDLLPGPPGV DEKSGNENCE PRSSGSGKRG KSNSRRRSTS
RGRSDSRNTS PSNTRRRHSL SRSLTPPRRR YDSPDYGRYS RRRFDRDRRR SPERRRSPPR
RGRRYGRSRS RSMSPRRGGR WSPKKKPSSP PVPPPHGGPH PQMTPGYGAM AAHIYGSYVA
PPDVYGHQYG IPPNSFPPQG PGYGIPGAPP DQSSFGSGYG PPPTSAWDVN VYGQQVWINQ
PISGVQPSAS DSLIQPQKAR ETLSGKTIGE EQSVPALEGA GLTPQDAVAQ EAEKQKDELK
KQRANYVKKV SLLKKEMKVL KDQREDLAAG DAPPSPTTKN FIEENDRLQM QIKKKLDTIE
NVIDMLNGII GYEEVEDEPS NQKSHGKTQP EQQDSRSHSS SESSADSSES SSSSSTASDS
SSDNEDGEGA GGAVGSPTNR LKHRAIKSMK SKQLHGEMKA VPTQAQNYNF VFFDPEQHWC
ESCGVFPKSA RDYLKHLHAE EHMNRETIET PWHVGIDHDP FPTFENAPAR RVPVRGMQFL
VPANAWFCKL CSVWIGDLHC ASAHLKSRLH SNKYQQFLNQ NPNYEIEWQT NRERAMNQQK
DHDDAKNKKS KKDEDKASKK RKKKGGDKKK KKRKHGKKSK RSTIDANSTS SSSDSSSSEE
ENGQQPKKGR TEQQPICQSD KSTNAASIRV AMRKQESTPT NLKPEVPCQP VVPPPPPIIK
DSTIPSERGK WTAASVEDQS KDQKNRDDTM LKQWNNVQPV ISESEKKLLE QLKGRLKNKG
ARDQNNHKAV PTEANDEKFR RGGGRHSRSR SKRRSYSRSI SRGRDRDRRD RERDRDRGRR
RRSRSRGRHF SRSPIRSSRR SRSRQGRSRR SRSRSIERVE RPVVKHSEFR PRTVPERKQT
DIKRDKKDAE SKSKSSKPSN NSLPGGKKLP FIGKMPVFKK QSVPSFNYDA SAVYTNGCLE
APPPPPPPLG GATSQIAVRQ QAPTAAQIQM AMMEDAFGNA PPFHPDAGMM VDYDELMPDP
VQFANLMTSC PPPPPPGEGS EGDAHGPEDG DQHDNENRED VLPPGIDEAE SALVPHPLDA
AAQSRDGELP KDLVEALDII FPSDVAILEA SNGNSEKQED VTITTIVEDD AVLSVIHLQD
LAKEGIHLVT INEAEVPKKS HIQTSEKIEK LQDLNGKSDD GVNIKLIDAE DIPMPNSPPA
EPSFDEETKS KALQKQADIS EIPEPAVSPS DSEKLRRQSE LDELAMLGID RSDMAAQYAL
