ID   Y978_PYRFU              Reviewed;         328 AA.
AC   Q8U271;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=UPF0252 protein PF0978;
GN   OrderedLocusNames=PF0978;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0252 family. {ECO:0000305}.
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DR   EMBL; AE009950; AAL81102.1; -; Genomic_DNA.
DR   RefSeq; WP_011012115.1; NC_003413.1.
DR   AlphaFoldDB; Q8U271; -.
DR   SMR; Q8U271; -.
DR   STRING; 186497.PF0978; -.
DR   EnsemblBacteria; AAL81102; AAL81102; PF0978.
DR   GeneID; 1468843; -.
DR   KEGG; pfu:PF0978; -.
DR   PATRIC; fig|186497.12.peg.1037; -.
DR   eggNOG; arCOG02164; Archaea.
DR   HOGENOM; CLU_045499_0_0_2; -.
DR   OMA; PYNNTIQ; -.
DR   OrthoDB; 66569at2157; -.
DR   PhylomeDB; Q8U271; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR007562; Transglutaminase-like_domain.
DR   Pfam; PF04473; DUF553; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="UPF0252 protein PF0978"
FT                   /id="PRO_0000159558"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  37793 MW;  8206BFD17BA27E76 CRC64;
     MRVPLLILLF LVLTSGCIAP STPSFTQTPT CLEQEKDLNK AIKCYLEDPR EIKALTNLSK
     SLKGPNEEWT IWNILKWEEE NLKYDDNKPT NYILRPSEFL VKRKGVCTDY TVLTLGLLLT
     LNYSQVGFMI VHYAESTTLH STAIANVSGT LFVLDQKLPP LDLGSYIVES GKAGKLITQG
     ELYYVSKSNG SIIIEGPTIL GANDFIRQDY KIDEQELKSI EIALKTMIAQ RSKLSQVYEL
     KYSLPRGFKE RRAWILKIPR FRVIYNPIFK EQYLETIIYH ILEDEEIKEH IKTATGFYLE
     VTTEQEDLII KFYLAKQYIY KGHNKNRG