Y9801_DROME
ID Y9801_DROME Reviewed; 709 AA.
AC Q0KIA2; Q8SXN8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=PP2C-like domain-containing protein CG9801;
GN ORFNames=CG9801;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF54282.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF54282.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAL90252.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND RNA EDITING OF POSITION 345.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL90252.1};
RC TISSUE=Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP RNA EDITING OF POSITION 345.
RX PubMed=17018572; DOI=10.1261/rna.254306;
RA Stapleton M., Carlson J.W., Celniker S.E.;
RT "RNA editing in Drosophila melanogaster: new targets and functional
RT consequences.";
RL RNA 12:1922-1932(2006).
CC -!- RNA EDITING: Modified_positions=345 {ECO:0000269|PubMed:12537569,
CC ECO:0000269|PubMed:17018572}; Note=Partially edited. Target of Adar.
CC {ECO:0000269|PubMed:17018572};
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DR EMBL; AE014297; AAF54282.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65127.1; -; Genomic_DNA.
DR EMBL; AY089514; AAL90252.1; -; mRNA.
DR RefSeq; NP_649827.2; NM_141570.3.
DR RefSeq; NP_731278.1; NM_169239.1.
DR RefSeq; NP_996184.1; NM_206462.2.
DR AlphaFoldDB; Q0KIA2; -.
DR BioGRID; 66219; 1.
DR IntAct; Q0KIA2; 1.
DR STRING; 7227.FBpp0081426; -.
DR PaxDb; Q0KIA2; -.
DR DNASU; 41044; -.
DR EnsemblMetazoa; FBtr0081944; FBpp0081426; FBgn0037623.
DR EnsemblMetazoa; FBtr0081945; FBpp0081427; FBgn0037623.
DR EnsemblMetazoa; FBtr0081946; FBpp0088976; FBgn0037623.
DR GeneID; 41044; -.
DR KEGG; dme:Dmel_CG9801; -.
DR UCSC; CG9801-RA; d. melanogaster.
DR FlyBase; FBgn0037623; CG9801.
DR VEuPathDB; VectorBase:FBgn0037623; -.
DR eggNOG; ENOG502QTP9; Eukaryota.
DR GeneTree; ENSGT00520000060965; -.
DR HOGENOM; CLU_016863_0_0_1; -.
DR InParanoid; Q0KIA2; -.
DR OMA; NGQNPTD; -.
DR OrthoDB; 1005058at2759; -.
DR PhylomeDB; Q0KIA2; -.
DR BioGRID-ORCS; 41044; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG9801; fly.
DR GenomeRNAi; 41044; -.
DR PRO; PR:Q0KIA2; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037623; Expressed in crop (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q0KIA2; baseline and differential.
DR Genevisible; Q0KIA2; DM.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR Gene3D; 3.60.40.10; -; 1.
DR InterPro; IPR036457; PPM-type_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase_dom.
DR SUPFAM; SSF81606; SSF81606; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; RNA editing.
FT CHAIN 1..709
FT /note="PP2C-like domain-containing protein CG9801"
FT /id="PRO_0000337167"
FT DOMAIN 259..503
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
FT REGION 121..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 345
FT /note="S -> G (in RNA edited version)"
FT /evidence="ECO:0000269|PubMed:17018572"
SQ SEQUENCE 709 AA; 76765 MW; A3B22F000FDE240D CRC64;
MPSLRQKVTT YFRQLSFIAE PREGRRRASE HEDDDGSFIT KYLEGRMQRQ FVEGPEIYNG
QNPTDMPVLK LDTYEAGNCS ITAACTGPDE GLTGIKRSKL HLSTSFADDI DFIDTQQEND
DCYGVRRSTP PVQVATQNST RLTSKFGRPP AGPRRQSSAE QPSGSASASG MRSRKNSKSS
IANLAAASAG TDAGKANSDQ NNRNVLNAKT EVSTDGDPNS ERERLLREAV SNQGGSDPAA
LIAGVENWRM ECDFAYGISV SLYETNMLTK EPMGNPIADC YGMVVRGDSA AMAMADGVNW
GDGARLAARS AVHGCLDYLD RAVFGQALEC RATTTQEVFV SLLRSLWEGH GCILEVGGAL
STLTIAVVLP LDGAPGKYVV CSCNVGDSLG YVYSKKHGVR ELTQASHDIS SMRDMRDALG
ALGPADGNKP ELSNLTFSMT CIESGDIVFL TSDGISDNFD PVVGKFAEAW TPDVKLQTSG
HVKPANLAPK RQNKSASAIY ARLHPSTPPT RPARQSKAES PPNNAPSRPK YMRSQTLIEP
RQGLVSAPPP SVVPQRIPKS ISGLPLVTGP QRHALTLYRL EDLLSYGING TFSPCVSARR
LCHLLIDFVR MITSARRKTL EQRELFYKLS TGPDGAKREV QLNRMQHRAA RKRVVDSSAF
VALPGKLDHA TVMAYTVGGG EEHNNGNENG DGGAISPVLQ SKEFKETNF
