Y986_MYCTU
ID Y986_MYCTU Reviewed; 248 AA.
AC P9WQK1; L0T5H7; O53899;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Uncharacterized ABC transporter ATP-binding protein Rv0986 {ECO:0000305};
GN OrderedLocusNames=Rv0986; ORFNames=MTV044.14;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=16586367; DOI=10.1086/502631;
RA Jain S.K., Paul-Satyaseela M., Lamichhane G., Kim K.S., Bishai W.R.;
RT "Mycobacterium tuberculosis invasion and traversal across an in vitro human
RT blood-brain barrier as a pathogenic mechanism for central nervous system
RT tuberculosis.";
RL J. Infect. Dis. 193:1287-1295(2006).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=MT103;
RX PubMed=17030567; DOI=10.1128/iai.00058-06;
RA Rosas-Magallanes V., Stadthagen-Gomez G., Rauzier J., Barreiro L.B.,
RA Tailleux L., Boudou F., Griffin R., Nigou J., Jackson M., Gicquel B.,
RA Neyrolles O.;
RT "Signature-tagged transposon mutagenesis identifies novel Mycobacterium
RT tuberculosis genes involved in the parasitism of human macrophages.";
RL Infect. Immun. 75:504-507(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Probably part of an ABC transporter complex involved in host
CC cell binding either through secretion of an adherence factor or through
CC maintaining the architecture and integrity of the mycobacterial cell
CC envelope. {ECO:0000269|PubMed:17030567}.
CC -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC (Rv0986) and two transmembrane proteins (Rv0987). {ECO:0000305}.
CC -!- INDUCTION: Highly up-regulated during the early stages of invasion of
CC the human blood-brain barrier. {ECO:0000269|PubMed:16586367}.
CC -!- DISRUPTION PHENOTYPE: Disruption of the gene reduces the ability of
CC M.tuberculosis to bind to host cells. Disruption does not reduce
CC virulence in a mouse model of infection. {ECO:0000269|PubMed:17030567}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AL123456; CCP43736.1; -; Genomic_DNA.
DR PIR; F70821; F70821.
DR RefSeq; NP_215501.1; NC_000962.3.
DR RefSeq; WP_003900248.1; NZ_NVQJ01000018.1.
DR AlphaFoldDB; P9WQK1; -.
DR SMR; P9WQK1; -.
DR STRING; 83332.Rv0986; -.
DR PaxDb; P9WQK1; -.
DR DNASU; 885364; -.
DR GeneID; 885364; -.
DR KEGG; mtu:Rv0986; -.
DR TubercuList; Rv0986; -.
DR eggNOG; COG1136; Bacteria.
DR OMA; LIRCMNL; -.
DR PhylomeDB; P9WQK1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0052572; P:response to host immune response; IMP:MTBBASE.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR017911; MacB_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Nucleotide-binding; Reference proteome; Transport.
FT CHAIN 1..248
FT /note="Uncharacterized ABC transporter ATP-binding protein
FT Rv0986"
FT /id="PRO_0000093254"
FT DOMAIN 7..246
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 248 AA; 27373 MW; 711E0BBC872BB81A CRC64;
MNRQPIVQLS NLSWTFREGE TRRQVLDHIT FDFEPGEFVA LLGQSGSGKS TLLNLISGIE
KPTTGDVTIN GFAITQKTER DRTLFRRDQI GIVFQFFNLI PTLTVLENIT LPQELAGVSQ
RKAAVVARDL LEKVGMADRE RTFPDKLSGG EQQRVAISRA LAHNPMLVLA DEPTGNLDSD
TGDKVLDVLL DLTRQAGKTL IMATHSPSMT QHADRVVNLQ GGRLIPAVNR ENQTDQPAST
ILLPTSYE
