ID   Y988_STRMU              Reviewed;         461 AA.
AC   P34001;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Uncharacterized protein SMU_988;
GN   OrderedLocusNames=SMU_988;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-373.
RX   PubMed=2761387; DOI=10.1111/j.1365-2958.1989.tb00193.x;
RA   Ferretti J.J., Russell R.R.B., Dao M.L.;
RT   "Sequence analysis of the wall-associated protein precursor of
RT   Streptococcus mutans antigen A.";
RL   Mol. Microbiol. 3:469-478(1989).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE014133; AAN58689.1; -; Genomic_DNA.
DR   EMBL; M37842; AAA88609.1; -; Genomic_DNA.
DR   PIR; S06993; S06993.
DR   RefSeq; NP_721383.1; NC_004350.2.
DR   AlphaFoldDB; P34001; -.
DR   SMR; P34001; -.
DR   STRING; 210007.SMU_988; -.
DR   DNASU; 1028330; -.
DR   EnsemblBacteria; AAN58689; AAN58689; SMU_988.
DR   KEGG; smu:SMU_988; -.
DR   PATRIC; fig|210007.7.peg.881; -.
DR   eggNOG; COG1502; Bacteria.
DR   HOGENOM; CLU_038053_1_2_9; -.
DR   OMA; EYCQRPL; -.
DR   PhylomeDB; P34001; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR   InterPro; IPR022924; Cardiolipin_synthase.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF13091; PLDc_2; 2.
DR   SMART; SM00155; PLDc; 2.
DR   TIGRFAMs; TIGR04265; bac_cardiolipin; 1.
DR   PROSITE; PS50035; PLD; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..461
FT                   /note="Uncharacterized protein SMU_988"
FT                   /id="PRO_0000201282"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          197..224
FT                   /note="PLD phosphodiesterase 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   DOMAIN          374..401
FT                   /note="PLD phosphodiesterase 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
SQ   SEQUENCE   461 AA;  53407 MW;  06973B61D90DAEAF CRC64;
     MIGSVLYLVN SQMDTLSIIT WLLVILPFPI LGTLFLIYTK QDWGYRELKS LIKKSTQAIK
     PYFQYDQRIL YKLKESHART YNLAQYLHRS GGFPVYKNTK VTYFPNGQSK FEEMKKQLLK
     AEKFIFLEYF IIAEGLMWGE ILSILEQKVQ EGVEVRVMYD GMLELSTLSF DYAKRLEKIG
     IKAKVFSPIT PFVSTYYNYR DHRKILVIDN KVAFNGGINL ADEYINQIER FGYWKDTAVM
     LEGEGVASFT LMFLQMWSTT NKDYEFAPYL TQNFHEIVAN GYVIPYSDSP LDHEKVGENV
     YIDILNQARD YVYIMTPYLI LDSEMEHALQ FAAERGVDVK IIMPGIPDKK VPFALAKRYF
     PALLDAGVKI YEFTPGFVHA KVFIADDIKA VVGTINLDYR SLYHHFECAT YMYQTDCLVD
     IKADFKETLK QSRRVTRSTL QKEKISTKLI GLVVKLVAPL L