Y988_THET2
ID Y988_THET2 Reviewed; 406 AA.
AC Q72IZ3;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Uncharacterized RNA methyltransferase TT_C0988;
DE EC=2.1.1.-;
GN OrderedLocusNames=TT_C0988;
OS Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=262724;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27;
RX PubMed=15064768; DOI=10.1038/nbt956;
RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL Nat. Biotechnol. 22:547-553(2004).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000255|PROSITE-
CC ProRule:PRU01024}.
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DR EMBL; AE017221; AAS81330.1; -; Genomic_DNA.
DR RefSeq; WP_011173408.1; NC_005835.1.
DR AlphaFoldDB; Q72IZ3; -.
DR SMR; Q72IZ3; -.
DR STRING; 262724.TT_C0988; -.
DR EnsemblBacteria; AAS81330; AAS81330; TT_C0988.
DR KEGG; tth:TT_C0988; -.
DR eggNOG; COG2265; Bacteria.
DR HOGENOM; CLU_014689_7_0_0; -.
DR OMA; CDPATWA; -.
DR OrthoDB; 1421660at2; -.
DR Proteomes; UP000000592; Chromosome.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR PANTHER; PTHR11061; PTHR11061; 2.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS01230; TRMA_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..406
FT /note="Uncharacterized RNA methyltransferase TT_C0988"
FT /id="PRO_0000162047"
FT ACT_SITE 364
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT BINDING 246
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT BINDING 273
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT BINDING 294
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT BINDING 337
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 406 AA; 44590 MW; C2417D659B802C42 CRC64;
MLTFRVEKLV PGGYGLARTE RGVVLVKGAL PGELVRGEPK RKKGALFLEA PEILEAHPGR
YPEPLPPSAD LPLAYEAQLP LKEALVRDAL ERVAKLEAPL APIRPSPRPL AYRTAAQYAR
HPLGGLAYRL PESHELHRLE KDPLLAEPLA WAFDVLKLWP LPVEEVALRG SLLEGKVLLG
LVGGVPEALK RPAKALVQEG FAGVVWAEPS PKGRFRGRVT PLAGERTLLE AFGPLKATVS
VESFSQVNPL AAGALLEEAR TLVFGGRRAL ELYAGSGLFS LLLSPRYEEV VAVEISKEAV
RRGEMDRKRL GAENVRFLRM DARKAEALGA FDLVVVDPPR AGLPPEVRAY LLRARPREIL
YVSCDPATWA RDVGALVQGG YRLAFARPYD FFPFTHHVEV LSLLRL
