Y9957_DICDI
ID Y9957_DICDI Reviewed; 1555 AA.
AC Q552C1;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Probable serine/threonine-protein kinase DDB_G0276181;
DE EC=2.7.11.1;
GN ORFNames=DDB_G0276181;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69390.1; -; Genomic_DNA.
DR RefSeq; XP_643307.1; XM_638215.1.
DR AlphaFoldDB; Q552C1; -.
DR SMR; Q552C1; -.
DR STRING; 44689.DDB0229957; -.
DR PaxDb; Q552C1; -.
DR EnsemblProtists; EAL69390; EAL69390; DDB_G0276181.
DR GeneID; 8620353; -.
DR KEGG; ddi:DDB_G0276181; -.
DR dictyBase; DDB_G0276181; -.
DR eggNOG; KOG0192; Eukaryota.
DR HOGENOM; CLU_246199_0_0_1; -.
DR InParanoid; Q552C1; -.
DR OMA; FNTCINR; -.
DR PRO; PR:Q552C1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..1555
FT /note="Probable serine/threonine-protein kinase
FT DDB_G0276181"
FT /id="PRO_0000355169"
FT DOMAIN 58..238
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 986..1309
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1156
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 992..1000
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 1061
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 1555 AA; 170901 MW; C2E85639CA22E8F5 CRC64;
MTSVGTTLIV KPANNSGGSD GNIKNNNNNN NNNNNNNNNN NNSNSGNNSN NNSFIDDQVL
HTGYLTKQGG RIQNWKIRWF VLKRGTLSYY LSPINWEYTK PRGVIYLTKK TELKEVDHRN
RRHCFAVNPN YISENQSIIQ QQQNQPILRS SSDSVNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNSKLYP NSTRIYLISA QTVFDKSKWI EMIKLAISSD
NSQDSKLKRA NHQLEKVKDL VFSNRKGSIP TFPSLLNRTI ATESLNDLIK VHLSKKRFYF
YHDNLTLPAL SYIDSESPVN LQEIHHQHLI LLQQQKEELN KKLKKIQQQN NIGGGGSGSN
IANSANKINN KNNDKINGVG SGEDKNNNKG GGGDNNSQSS SSSVSPTTVS PSVSPLSSSP
TKPPIILSKK PLPTPPRNIS TSDNGSGTDS PFYNSAITRL PLISTSVGMV GPNGMVNITS
MNTTTTTTTT TTTTAPTTTN TNTNIKPLPG IQQNKLQLIQ NKDGGGGGGG VLKRTNPLLS
TSAPSMAYNQ LVANSGIIHK HQPKIVVFHL VRDSFQISNI GGCSFNFEIL SPFDPNFTLN
FIPSSGTIQK GDSLTVLVEL MAYNHIETDI YSTLHIIGGM EFTLFCRIET DPYLPLFLKS
CAGSVLPLEK QMKMESFMKK NPTMVKSIQE LAHTLILDGR NIIPLHLSNN ININNNNNNG
GGGSGYNIGG GSNNSIGGSG SNNNSNVNIS NGWNIENSNR RNSGGCLNLV GGSGGGGLIN
NNINNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNGSGLLSSS
PLITISNQNT PTPQARVKLS KYILNFQRNQ KKNSVGDVES VKIYQLLTDK FLISNSGSAD
ASFQFHFPSR GKKNDLFSLS LVPTNGTVSK GEWFYIKSTL TVFVETEISE MIQLIINQRE
VHHILITVKC ENIHPGNKEI DLEKEVVLHE RLGTGATGDI YRGLISQDNL NRHISNQDSS
GSNSSGSGSG HNWLIARNPS NDIINKDAII GSGPQIIVAV KKLHPLADPS PEMIQDFYNE
VRVLSMFNHP NVVKYVGGCT KIANWSIVME YVPGGNLMDV LANPVLVIPY KLVLRMALDI
AKGLHYLHSL GILHLDMKSP NLLVSSLSTS AKVNIKVADF NTCINRSRIT AGFFNRHTGS
GDNNKVEKDS KKGTTLWMAP EVIRGAMYSE KCDVYSFAII MWEMVTRKLP YSHIAFNCEV
EDQVLKGLRP PIPMHCNKNY TDLMEQCWDD DPENRPYFDT IIHSISKMIE SNDITEQKAK
ASFKGLRRTQ SNSTLNLLQV QNNNNNSNNN NNNNNNNNNN NSNSNLNNCN NSSPNLGTNS
ANNDSGVSVL QTCSDIGVGS TGTNSGTSGT NSGFDSPVIV TKDYHLISNL QKLDLHSNDG
SDTNGSQIGF KSDINSKKSS LEVHSKHKSK RFSYDGGSSR ASINTLNNDS NLPFKFSPPS
TPQSSFLQLK KLDKELKSNL ESNAGTKHSF IRYKPSFTNV TSAKSKLNLN NNNNN
