ID   Y996_METJA              Reviewed;         451 AA.
AC   Q58403;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Metalloprotease MJ0996;
DE            EC=3.4.-.-;
GN   OrderedLocusNames=MJ0996;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Probable metalloprotease. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase U62 family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99001.1; -; Genomic_DNA.
DR   PIR; D64424; D64424.
DR   RefSeq; WP_010870510.1; NC_000909.1.
DR   AlphaFoldDB; Q58403; -.
DR   SMR; Q58403; -.
DR   STRING; 243232.MJ_0996; -.
DR   EnsemblBacteria; AAB99001; AAB99001; MJ_0996.
DR   GeneID; 1451894; -.
DR   KEGG; mja:MJ_0996; -.
DR   eggNOG; arCOG00321; Archaea.
DR   HOGENOM; CLU_026425_1_2_2; -.
DR   InParanoid; Q58403; -.
DR   OMA; TDFWGSM; -.
DR   OrthoDB; 22382at2157; -.
DR   PhylomeDB; Q58403; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; -; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   Pfam; PF01523; PmbA_TldD; 1.
DR   Pfam; PF19289; PmbA_TldD_C; 1.
DR   Pfam; PF19290; PmbA_TldD_M; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; SSF111283; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metalloprotease; Protease; Reference proteome.
FT   CHAIN           1..451
FT                   /note="Metalloprotease MJ0996"
FT                   /id="PRO_0000142364"
SQ   SEQUENCE   451 AA;  49814 MW;  D5245F2E9551FB79 CRC64;
     MLNLEKIEKL LEVGDYADIR INFGESNTIT LKDGKIEEIS SGFGNGVAVR VLYKNGWGFV
     TSNIVSEEEI EKLINKAYKM AKISNEYSEK EIILKDYKAI IDNYKMIGKI NPTDVDIEEK
     KEIIIDTYKN MTDEKIKSIS VSYSDVFGKR IFMISEGSRI EGEITRCIMY MNCVAKENGN
     LQYGAERTGG FGFEKIKDNY LNLALEAKNR ALRLLKAKPC PKGKFKVILD PELAGVFIHE
     AVGHASEADL VLQNDSVFKD KLGERVGSEY VTVIDDATIE GAFGSYKYDD EGVEGKKTVI
     IENGILKTYL HSRETAGRMD AELTGNGRAE GLNKPIVRMS NTFIKPGDWS FEELLEDTKE
     GIFLKGSRGG QVDTGKGLFQ FSAVEAYLIE NGELTQVLKD AGLSGEILDI LFKVDAVTKD
     FELSVGYCGK DGQSVPVGDG GGCVRTIATV S