ID   Y996_STRR6              Reviewed;         226 AA.
AC   Q8DPU7;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=UPF0758 protein spr0996;
GN   OrderedLocusNames=spr0996;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
RN   [2]
RP   DISRUPTION PHENOTYPE, AND SHOWS THAT THIS IS NOT RADC.
RX   PubMed=18556794; DOI=10.1128/jb.00425-08;
RA   Attaiech L., Granadel C., Claverys J.P., Martin B.;
RT   "RadC, a misleading name?";
RL   J. Bacteriol. 190:5729-5732(2008).
CC   -!- DISRUPTION PHENOTYPE: Mutants show normal uptake and processing of
CC       transforming DNA. They also display normal sensitivity to DNA-damaging
CC       agents. {ECO:0000269|PubMed:18556794}.
CC   -!- SIMILARITY: Belongs to the UPF0758 family. {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be the site of the radC102 mutation,
CC       but it was subsequently shown that it is not the case.
CC       {ECO:0000305|PubMed:18556794}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK99800.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE007317; AAK99800.1; ALT_INIT; Genomic_DNA.
DR   PIR; D97996; D97996.
DR   RefSeq; NP_358590.1; NC_003098.1.
DR   RefSeq; WP_000286923.1; NC_003098.1.
DR   AlphaFoldDB; Q8DPU7; -.
DR   SMR; Q8DPU7; -.
DR   STRING; 171101.spr0996; -.
DR   EnsemblBacteria; AAK99800; AAK99800; spr0996.
DR   GeneID; 60232431; -.
DR   KEGG; spr:spr0996; -.
DR   PATRIC; fig|171101.6.peg.1084; -.
DR   eggNOG; COG2003; Bacteria.
DR   HOGENOM; CLU_073529_0_2_9; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd08071; MPN_DUF2466; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR025657; RadC_JAB.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001405; UPF0758.
DR   InterPro; IPR020891; UPF0758_CS.
DR   PANTHER; PTHR30471; PTHR30471; 1.
DR   Pfam; PF04002; RadC; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   TIGRFAMs; TIGR00608; radc; 1.
DR   PROSITE; PS50249; MPN; 1.
DR   PROSITE; PS01302; UPF0758; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..226
FT                   /note="UPF0758 protein spr0996"
FT                   /id="PRO_0000190738"
FT   DOMAIN          103..225
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   MOTIF           174..187
FT                   /note="JAMM motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         174
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         176
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         187
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   226 AA;  25522 MW;  235A63A06B302524 CRC64;
     MYSISFQEDS LLPRERLAKE GVEALSNQEL LAILLRTGTR QASVFEIAQK VLNNLSSLTD
     LKKMTLQELQ SLSGIGRVKA IELQAMIELG HRIHKHETLE MESILSSQKL AKKMQQELGD
     KKQEHLVALY LNTQNQIIHQ QTIFIGSVTR SIAEPREILH YAIKHMATSL VLVHNHPSGA
     VAPSQNDDHV TKLVKEACEL MGIVLLDHLI VSHSNYFSYR EKTDLI