ID   CATA_ONCVE              Reviewed;         482 AA.
AC   Q27710; O85499;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Catalase;
DE            EC=1.11.1.6;
GN   Name=cat;
OS   Onchocerca volvulus endobacterium.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia; unclassified Wolbachia.
OX   NCBI_TaxID=77551;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Henkle-Duehrsen K.J.;
RL   Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Henkle-Duehrsen K.J., Eckelt V.H.O., Wildenburg G., Blaxter M.L.,
RA   Walter R.D.;
RT   "Gene structure, activity and localization of a catalase from intracellular
RT   bacteria in Onchocerca volvulus.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to
CC       protect cells from the toxic effects of hydrogen peroxide.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10013};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC   -!- SIMILARITY: Belongs to the catalase family. {ECO:0000305}.
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DR   EMBL; X82176; CAA57666.1; -; mRNA.
DR   EMBL; AF069070; AAC79431.1; -; Genomic_DNA.
DR   PIR; S49465; S49465.
DR   AlphaFoldDB; Q27710; -.
DR   SMR; Q27710; -.
DR   PRIDE; Q27710; -.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd08156; catalase_clade_3; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR040333; Catalase_3.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; PTHR11465; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   2: Evidence at transcript level;
KW   Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.
FT   CHAIN           1..482
FT                   /note="Catalase"
FT                   /id="PRO_0000084993"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        55
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   ACT_SITE        128
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   BINDING         338
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   482 AA;  53700 MW;  B1DA5F49BA39F776 CRC64;
     MSQNKTLTTA SGPPVADNQN SRSAGPRGPL LLDDFHLIEK LAHFNRENIP ERRVHAKGSG
     AYGTFTVTQD ITQYTSAKLF DSVGKQTPTF LRFSTVGGER GSADTERDPR GFALKFYTEE
     GNWDIVGNNT PVFFIRDPLK FPDFIHTQKR LPQSNLKSAQ MMWDFWSHSP EALHQVTILF
     SDRGIPDGYR HMHGFGSHTY SLINAKGERH WVKWHYKTKQ GIKNLAPADA ARLAGTDPDY
     AQRDLFGAIE RGDFPKWRVC IQIMTEAQAN AHYENPFDVT KTWSQKEFPL IEVGELELNR
     NPLNYFAEVE QAAFGPSNMV PGVGLSPDRM LQGRVFAYAD AHRYRVGTNH QQLPVNAPRS
     PVNSYQRDGS MAFGSNGGAA PNYEPNSYAD APKQAPQYAE PALALSGAAD RYDHREDTDY
     YSHAGALFRL MNDEQKALLI NNIAGAMAGV SSDVVQRQLQ YFFKADPAYG EGIASALGVS
     LN