ID   YA00_PYRHO              Reviewed;         355 AA.
AC   O58728;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Putative transport protein PH1000;
GN   OrderedLocusNames=PH1000;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC       family. {ECO:0000305}.
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DR   EMBL; BA000001; BAA30097.1; -; Genomic_DNA.
DR   PIR; C71092; C71092.
DR   AlphaFoldDB; O58728; -.
DR   STRING; 70601.3257414; -.
DR   EnsemblBacteria; BAA30097; BAA30097; BAA30097.
DR   KEGG; pho:PH1000; -.
DR   eggNOG; arCOG02642; Archaea.
DR   OMA; EIAYVYQ; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002549; AI-2E-like.
DR   PANTHER; PTHR21716; PTHR21716; 1.
DR   Pfam; PF01594; AI-2E_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..355
FT                   /note="Putative transport protein PH1000"
FT                   /id="PRO_0000148328"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   355 AA;  40180 MW;  D0929BBFEA847F39 CRC64;
     MRTWKMRKDG QRIDYLGRKW RNLGGPFMEV SRVVTWIIII TLVALAIKTI LPFFSPLFFA
     FITAYALYPL HIKLKERIGS KNSAILLTLF LLLGALMILL ILVYTLTPVI GQAYDYLTNL
     EKIKINIPLV PKSVISSLEG VIDEFIERGK GYLVSLTFSV PKYLLQVIVY LTFVYFFLVK
     EKEARELITF EDEKLIRIIE RGNLTLQALI RVWLLLNIVK GILMTLGFLI FKVSNLPTAI
     LAGLLTVLFS FIPLFEGWMI WLAGAFYLVK QGHIIAGIGL AVYGFTLVSP LPDFTIRPKL
     VAREAEFNDV LVLIGMIGGT WGLGLKGLII GPIVLNVAIE MLREWKNVQA KTERS