ID   YA075_YEAST             Reviewed;         157 AA.
AC   O42831;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W;
GN   OrderedLocusNames=YAR075W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RA   Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B.,
RA   Kaback D.B., Clark M.W.;
RT   "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52
RT   Kbp CDC15-FLO1-PHO11-YAR074 region.";
RL   Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA   Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA   Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA   Storms R.K.;
RT   "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   IDENTIFICATION AS PSEUDOGENE.
RX   PubMed=12746440; DOI=10.1074/jbc.m303736200;
RA   Hyle J.W., Shaw R.J., Reines D.;
RT   "Functional distinctions between IMP dehydrogenase genes in providing
RT   mycophenolate resistance and guanine prototrophy to yeast.";
RL   J. Biol. Chem. 278:28470-28478(2003).
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene unlikely to encode a
CC       functional protein. In strain S288c, this gene has a frameshift
CC       compared to the other IMD alleles, producing 2 ORFs YAR073W and
CC       YAR075W. Because of that it is not part of the S.cerevisiae S288c
CC       complete/reference proteome set. {ECO:0000305|PubMed:12746440,
CC       ECO:0000305|PubMed:24374639}.
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DR   EMBL; L28920; AAC09511.1; -; Genomic_DNA.
DR   EMBL; AY692623; AAT92642.1; -; Genomic_DNA.
DR   PIR; S78078; S78078.
DR   AlphaFoldDB; O42831; -.
DR   SMR; O42831; -.
DR   IntAct; O42831; 1.
DR   MINT; O42831; -.
DR   STRING; 4932.YAR075W; -.
DR   iPTMnet; O42831; -.
DR   MaxQB; O42831; -.
DR   PaxDb; O42831; -.
DR   PRIDE; O42831; -.
DR   EnsemblFungi; YAR075W_mRNA; YAR075W; YAR075W.
DR   SGD; S000002145; YAR075W.
DR   eggNOG; KOG2550; Eukaryota.
DR   HOGENOM; CLU_022552_5_4_1; -.
DR   OMA; GEYFHHE; -.
DR   GO; GO:0003938; F:IMP dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   PANTHER; PTHR11911; PTHR11911; 1.
DR   Pfam; PF00478; IMPDH; 1.
PE   5: Uncertain;
FT   CHAIN           1..157
FT                   /note="Putative inosine-5'-monophosphate dehydrogenase-like
FT                   protein YAR075W"
FT                   /id="PRO_0000248413"
SQ   SEQUENCE   157 AA;  17003 MW;  90F3FCF03C244FCF CRC64;
     MVVFKNIGHI ITKALALGSS TVMMGGMLAG TTESPGEYLY QDGKRLKAYR GMGSIDAMQK
     TGTKGNASTS RYFSESDSVL VAQGVSGAVV DKGSIKKFIP YLYNGLQHSC QDIGCRSLTL
     LKENVQSGKV RFEFRTASAQ LEGGVNNLHS YEKRLHN