ID   YA32_SCHPO              Reviewed;         394 AA.
AC   Q09709;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Pseudouridylate synthase C18B11.02c {ECO:0000305};
DE            EC=5.4.99.- {ECO:0000250|UniProtKB:Q8IZ73};
GN   ORFNames=SPAC18B11.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Pseudouridine synthase that catalyzes pseudouridylation of
CC       RNAs. {ECO:0000250|UniProtKB:Q8IZ73}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000250|UniProtKB:Q8IZ73};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAA90587.1; -; Genomic_DNA.
DR   PIR; T37912; S58301.
DR   RefSeq; NP_592881.1; NM_001018281.2.
DR   AlphaFoldDB; Q09709; -.
DR   SMR; Q09709; -.
DR   BioGRID; 279061; 13.
DR   STRING; 4896.SPAC18B11.02c.1; -.
DR   MaxQB; Q09709; -.
DR   PaxDb; Q09709; -.
DR   EnsemblFungi; SPAC18B11.02c.1; SPAC18B11.02c.1:pep; SPAC18B11.02c.
DR   GeneID; 2542607; -.
DR   KEGG; spo:SPAC18B11.02c; -.
DR   PomBase; SPAC18B11.02c; -.
DR   VEuPathDB; FungiDB:SPAC18B11.02c; -.
DR   eggNOG; KOG1919; Eukaryota.
DR   HOGENOM; CLU_016902_12_4_1; -.
DR   InParanoid; Q09709; -.
DR   OMA; VAYHDEM; -.
DR   PhylomeDB; Q09709; -.
DR   PRO; PR:Q09709; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005739; C:mitochondrion; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; ISO:PomBase.
DR   GO; GO:0009982; F:pseudouridine synthase activity; ISO:PomBase.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; ISO:PomBase.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..394
FT                   /note="Pseudouridylate synthase C18B11.02c"
FT                   /id="PRO_0000162755"
FT   ACT_SITE        156
FT                   /evidence="ECO:0000250|UniProtKB:P0AA37"
SQ   SEQUENCE   394 AA;  44899 MW;  4C8CC4D97CE8E3FA CRC64;
     MLKRPKRDPL KDCEYVFKGD GLRRVPPYYY EYITFAKLRW YGKTLLEVFN TEFRDRESGY
     YEKAIRNGQV KVNNQIGNVD TLIENGYIVS HHAHRHEPPV SDQPVGIVHE DESYVVIDKP
     AGVPVHPTGR YNHNTVLHIL MKENKCSLLY PCNRLDRLTS GLMFFSKSPK AAEEMRVHMI
     SKSLKKEYVA RVIGEFPNSG EVICDAPLLT VAPTLGLNRI HPDGKEASTV FKRIAFDGHT
     SLVLCKPLTG RTHQLRVHLQ YLGYPIANDP IYANKRVWGP SLGKNGEGSN ESVIMRLSEI
     GKTETASPLL QYEWYTNETE AEAKARRDKR LGELLTGKHC SECGTPLYSD PSPEELGIWL
     HALKYESKDW SYKTQLPKWA LDVCCRDPNA LPIE