ID   YA44_HELPJ              Reviewed;         370 AA.
AC   Q9ZM43;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Uncharacterized metallophosphoesterase jhp_0380;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=jhp_0380;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE001439; AAD05967.1; -; Genomic_DNA.
DR   PIR; B71937; B71937.
DR   RefSeq; WP_000908744.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZM43; -.
DR   STRING; 85963.jhp_0380; -.
DR   EnsemblBacteria; AAD05967; AAD05967; jhp_0380.
DR   KEGG; hpj:jhp_0380; -.
DR   PATRIC; fig|85963.30.peg.631; -.
DR   eggNOG; COG1408; Bacteria.
DR   OMA; MQFGIEI; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding.
FT   CHAIN           1..370
FT                   /note="Uncharacterized metallophosphoesterase jhp_0380"
FT                   /id="PRO_0000172856"
FT   BINDING         152
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         154
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         184
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         184
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         215
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         306
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         308
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   370 AA;  42169 MW;  B96032C6B737EC6E CRC64;
     MLISIAFLLV LCLLNYSSFR MLKSFLTLKK ISRYAYLGFF ILLSAGEATF VFYRNVMPSH
     LFVLTSACSF VSFIAFVFSL SFYGFSYSVE KIDFLPSRRK GLKNFLRIGF YLALLGYFWR
     GFYEGLARPK IKETPIYLDK LDKELKIILL TDMHVGSLLQ KDFVNYIVEE VNQKEVDMVL
     IGGDLVDENI EKVKSFLLPL NNLKSTHGTF YVPGNHEYYH GIEPILSFLN TLDMTILGNE
     CVHLGGINLC GVYDYFARKR QDFAPDIDKA LKKRDSSKPT ILLAHQPKQI RSLKESHSID
     LVLSGHTHAG QIFPFSLLVK LAQTYLHGLY KHSGTTQIYV SSGAGYWGIP LRFLAPSEIA
     YLRLLPKNQA