YA4C_SCHPO
ID YA4C_SCHPO Reviewed; 596 AA.
AC Q09729;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Arrestin domain-containing protein C31A2.12;
GN ORFNames=SPAC31A2.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-373; THR-374; SER-452;
RP SER-474; SER-493; SER-497; THR-502; THR-507 AND SER-514, AND IDENTIFICATION
RP BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR EMBL; CU329670; CAA90470.1; -; Genomic_DNA.
DR PIR; T38610; S58106.
DR RefSeq; NP_592924.1; NM_001018325.2.
DR AlphaFoldDB; Q09729; -.
DR BioGRID; 279381; 49.
DR STRING; 4896.SPAC31A2.12.1; -.
DR iPTMnet; Q09729; -.
DR SwissPalm; Q09729; -.
DR MaxQB; Q09729; -.
DR PaxDb; Q09729; -.
DR PRIDE; Q09729; -.
DR EnsemblFungi; SPAC31A2.12.1; SPAC31A2.12.1:pep; SPAC31A2.12.
DR GeneID; 2542940; -.
DR KEGG; spo:SPAC31A2.12; -.
DR PomBase; SPAC31A2.12; -.
DR VEuPathDB; FungiDB:SPAC31A2.12; -.
DR eggNOG; KOG3780; Eukaryota.
DR HOGENOM; CLU_018982_2_0_1; -.
DR InParanoid; Q09729; -.
DR OMA; GMATPFH; -.
DR PhylomeDB; Q09729; -.
DR Reactome; R-SPO-844456; The NLRP3 inflammasome.
DR PRO; PR:Q09729; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; ISM:PomBase.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; ISO:PomBase.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; IBA:GO_Central.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..596
FT /note="Arrestin domain-containing protein C31A2.12"
FT /id="PRO_0000116393"
FT TRANSMEM 194..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 363..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 373
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 374
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 452
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 474
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 493
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 497
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 502
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 507
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 514
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 596 AA; 65902 MW; C93B9FA55688E7B1 CRC64;
MNILSRKENV ASYFDIRVAA EHDLIVIQGL ADSAEPTPLS GSVVLCLNEA ISVKAISLKL
VGKCRISWSE PSPTVRGGQR HNKQEYVVYE KNWIFVPYTG ANRTLRAGNY EYPFHVMLPG
DIAESVEGLQ SCYVVYRLKA SIDRTGLASK MVKKKHIRLI RALPADAIEY TQTISVDNTW
PNKIEYTISV PTKAYAIGSY IPIHFVLVPL LKRLTIGKIS ITLKEYITLH VAHGYNGLPA
SKDEVRTVRS LQTEELEEFS DHYELTKNLE LPSSLVECLQ DCDLDGIKIR HKLKFSVSLR
NPDGHISELR AALPVVLMIP PQLFGDRAEV ESLRENFESF NQPLPSYQNS MYDRLYDGLS
YSNLDTPLPS GATTPRRRDS MEPTYASNEA HRRQLIAGLT ELALQQQPQG RSPNEHSPSN
HPEDFPPSFS LGSNPSSGAA SAVITRNPSE TSLADLSRVP SYKEATRSAV PLESPLQSTL
PSYEDVARIE HLSRPPSPGI VTPPQRTSPS FFVSPTESTR QSLDSRRSFE HSTSSSSGIS
PSHSSASLAH LSQASNPNGS SSAPHRPTSA RVGSHRNALD ALRRARMLPS GFSRRN
