YA7D_SCHPO
ID YA7D_SCHPO Reviewed; 871 AA.
AC Q09766; Q9USD2;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Uncharacterized membrane protein C24H6.13;
GN ORFNames=SPAC24H6.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 570-782, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-725; SER-726; SER-727;
RP SER-729; SER-737 AND SER-761, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:10759889,
CC ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
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DR EMBL; CU329670; CAA90857.1; -; Genomic_DNA.
DR EMBL; AB027849; BAA87153.1; -; Genomic_DNA.
DR PIR; S62415; S62415.
DR RefSeq; NP_592939.1; NM_001018340.2.
DR AlphaFoldDB; Q09766; -.
DR SMR; Q09766; -.
DR BioGRID; 278166; 24.
DR STRING; 4896.SPAC24H6.13.1; -.
DR iPTMnet; Q09766; -.
DR MaxQB; Q09766; -.
DR PaxDb; Q09766; -.
DR PRIDE; Q09766; -.
DR EnsemblFungi; SPAC24H6.13.1; SPAC24H6.13.1:pep; SPAC24H6.13.
DR GeneID; 2541670; -.
DR KEGG; spo:SPAC24H6.13; -.
DR PomBase; SPAC24H6.13; -.
DR VEuPathDB; FungiDB:SPAC24H6.13; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_2_1_1; -.
DR InParanoid; Q09766; -.
DR OMA; NWACVAL; -.
DR PhylomeDB; Q09766; -.
DR PRO; PR:Q09766; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium activated cation channel activity; ISS:PomBase.
DR GO; GO:0098655; P:cation transmembrane transport; ISS:PomBase.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR032880; Csc1_N.
DR InterPro; IPR027815; PHM7_cyt.
DR InterPro; IPR022257; PHM7_ext.
DR InterPro; IPR003864; RSN1_7TM.
DR PANTHER; PTHR13018; PTHR13018; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 1: Evidence at protein level;
KW Calcium; Golgi apparatus; Ion channel; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..871
FT /note="Uncharacterized membrane protein C24H6.13"
FT /id="PRO_0000116398"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 727..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 725
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 726
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 727
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 729
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 737
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 761
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 871 AA; 98443 MW; D286E1F105DBB0F2 CRC64;
MSDSSSSSTS AFVSSLVFNF AIFCAFIGLF LCLRPREKHV YQPRCIIDTQ PKEEKPEPSP
SSPFGLFAYV VKRSETYLIQ YAGVDGYFFI RYLFTFGALC ILGCLVLFPI LLPVNATNGV
GEKGFDILSF SNVKNHNRFY AHVFLSWLFF GFTIFIIYRE LRYYVIFRHA MQSSGLYNNL
PSSSTMLLTE LPNSVLNDEE TLHELFPNAS EFTCVRDLKK LEKKVKKRSD LGNKYESTLN
SLINKSVKKH NKLVKKHKPL PSTLDYTAYV KKRPTHRLKF LIGKKVDTID YCRDTIAELD
EVVDKLQTSL EERKKVGSVF IRFRSQTDLQ TAYQAFLYSK KFRKYRFGRA LVGIAPEDIV
WSNLDLSMYT RRGKKTISNT ILTLMIIFWA FPVAVVGCIS NVNYLIEKVH FLKFIDHMPP
KLLGIITGIL PSVALSILMS LVPPFIKFLG KFGGALTVQE IENYCQNWYY AFQVVQVFLV
TTMTSAATSA VVQVIKEPAS SMTLLASNLP KASNFYISYF LLQGLSIPGG ALLQIVTLLL
SKVLGRIFDN TPRKKWNRWN QLSAPSWGTV YPVYSLLVTI MICYSIIAPI IIGFAAVAFV
LIYFAYSYNL IYVLGHNADA KGRNYPRALF QVFVGLYLAE VCLIGLFVLA KNWGATVLEA
VFLGFTVACH LYFKYKFLPL MDAVPISAIE SVSERPEIKY PMDLGTSEMK NVGRAYPEIL
EKLSSSSGSD EFLETSSRTS ENTKEKIDKD DEGFAITNIS SVHKMPSFVL SYFSDLAASN
RILTGFDRVL QLLPSFYDIP VRVRNVQYVS PALKATPPSV WIPKDPLGLS TYAIEDARGK
VDIFDDNTTF NEKGNLQYTG PPPDYDEAIR S
