YAA1_SCHPO
ID YAA1_SCHPO Reviewed; 598 AA.
AC Q09795; Q9URW5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 4.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Uncharacterized peptidase C22G7.01c;
DE EC=3.4.-.-;
GN ORFNames=SPAC22G7.01c, SPAPJ696.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000305};
CC Note=Binds 2 manganese ions per subunit. {ECO:0000305};
CC -!- SIMILARITY: Belongs to the peptidase M24B family. {ECO:0000305}.
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DR EMBL; CU329670; CAB62423.2; -; Genomic_DNA.
DR PIR; T11611; T11611.
DR PIR; T50297; T50297.
DR RefSeq; XP_001713044.1; XM_001712992.2.
DR AlphaFoldDB; Q09795; -.
DR SMR; Q09795; -.
DR STRING; 4896.SPAC22G7.01c.1; -.
DR MEROPS; M24.009; -.
DR MaxQB; Q09795; -.
DR PaxDb; Q09795; -.
DR PRIDE; Q09795; -.
DR EnsemblFungi; SPAC22G7.01c.1; SPAC22G7.01c.1:pep; SPAC22G7.01c.
DR PomBase; SPAC22G7.01c; -.
DR VEuPathDB; FungiDB:SPAC22G7.01c; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_3_1; -.
DR InParanoid; Q09795; -.
DR OMA; YRPGKWG; -.
DR PhylomeDB; Q09795; -.
DR PRO; PR:Q09795; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0034396; P:negative regulation of transcription from RNA polymerase II promoter in response to iron; ISO:PomBase.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.40.350.10; -; 2.
DR Gene3D; 3.90.230.10; -; 1.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF53092; SSF53092; 2.
DR SUPFAM; SSF55920; SSF55920; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Hydrolase; Manganese; Metal-binding; Reference proteome.
FT CHAIN 1..598
FT /note="Uncharacterized peptidase C22G7.01c"
FT /id="PRO_0000185095"
FT BINDING 397
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 408
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 408
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 506
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 520
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 520
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 598 AA; 66681 MW; 9F843F70FB2A893F CRC64;
MVVHTGNRLN KLRELMKERG YTLYVVPSED AHSSEYTCDA DARRAFISGF DGSAGCAVIG
ETSAALFTDG RYFNQASQQL DENWTLMKQG FTGVPTWEEY CTQMTKCNEK VGIDSSLITF
PAAKALRESL FLKSGAVLVG DHDNLVDIVW GASRPKEPLE KLIVQEIKYA GLGVDEKLHN
LREAMKEQKI EAFVVSMLDE VAWLYNLRGA DVPYNPVFFA YSLVTLDEAF LYVDERKVTP
EVSKHLDGFV KILPYDRVFS DAKNSNLTRI GISSKTSWCI ATSFGETKVM PILSPISQAK
GIKNDAELKG MKECHIRDGC ALVEYFAWLD EYLNSGNKIN EFDAATKLEQ FRRKNNLFMG
LSFETISSTG PNGAVIHYSP PATGSAIIDP TKIYLCDSGA QYKDGTTDVT RTWHFGEPSE
FERQTATLAL KGHIALANIV FPKGTTGYMI DVLARQYLWK YGLDYLHGTG HGVGSFLNVH
ELPVGIGSRE VFNSAPLQAG MVTSNEPGFY EDGHFGYRVE NCVYITEVNT ENRFAGRTYL
GLKDLTLAPH CQKLIDPSLL SPEEVKYLNE YHSEVYTTLS PMLSVSAKKW LSKHTSPI
