YAC4_SCHPO
ID YAC4_SCHPO Reviewed; 489 AA.
AC Q09818;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Putative general negative regulator of transcription C16C9.04c;
GN ORFNames=SPAC16C9.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: May negatively regulate the basal and activated transcription
CC of many genes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAA91192.1; -; Genomic_DNA.
DR PIR; T37777; S62474.
DR RefSeq; NP_593078.1; NM_001018475.2.
DR AlphaFoldDB; Q09818; -.
DR SMR; Q09818; -.
DR BioGRID; 278791; 11.
DR STRING; 4896.SPAC16C9.04c.1; -.
DR iPTMnet; Q09818; -.
DR MaxQB; Q09818; -.
DR PaxDb; Q09818; -.
DR PRIDE; Q09818; -.
DR EnsemblFungi; SPAC16C9.04c.1; SPAC16C9.04c.1:pep; SPAC16C9.04c.
DR GeneID; 2542325; -.
DR KEGG; spo:SPAC16C9.04c; -.
DR PomBase; SPAC16C9.04c; -.
DR VEuPathDB; FungiDB:SPAC16C9.04c; -.
DR eggNOG; KOG2068; Eukaryota.
DR HOGENOM; CLU_028046_0_0_1; -.
DR InParanoid; Q09818; -.
DR OMA; TEENVQW; -.
DR PhylomeDB; Q09818; -.
DR PRO; PR:Q09818; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0030014; C:CCR4-NOT complex; IDA:PomBase.
DR GO; GO:0030015; C:CCR4-NOT core complex; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; EXP:PomBase.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:PomBase.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IDA:PomBase.
DR GO; GO:0070647; P:protein modification by small protein conjugation or removal; IC:PomBase.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd16618; mRING-HC-C4C4_CNOT4; 1.
DR CDD; cd12438; RRM_CNOT4; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR034261; CNOT4_RRM.
DR InterPro; IPR039780; Mot2.
DR InterPro; IPR039515; NOT4_mRING-HC-C4C4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12603; PTHR12603; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Metal-binding; Nucleus; Reference proteome; Repressor;
KW RNA-binding; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..489
FT /note="Putative general negative regulator of transcription
FT C16C9.04c"
FT /id="PRO_0000081682"
FT DOMAIN 116..198
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 18..61
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 199..226
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 246..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..109
FT /evidence="ECO:0000255"
FT COMPBIAS 246..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 54418 MW; 237C2EF4D44221F7 CRC64;
MLKTQEIYSS EDEDDMCCPL CMEEIDISDK NFKPCQCGYR VCRFCWHHIK EDLNGRCPAC
RRLYTEENVQ WRPVTAEEWK MDLHRKNERK KREKERKEVE LSNRKHLANI RVVQKNLAYV
NGLSPKVANE ENINVLKGPE YFGQYGKIIK IAINKKAAAN SANGHVGVYI TYQRKEDAAR
AIAAIDGSVS DGRHLRASYG TTKYCTSYLR NQQCPNPSCM YLHEPGDEVD SYTKEDLASL
QHTRPLSTKP NVVNGATHSP SPSLPFKTPL LPVTKTPLEE ANSSPAAQNQ HITTVDHVHP
QVSMTPSLST NNTATSVPAP YSSAASVNVV PGHATTILHH EESSALPPTA AWAKLSPSVL
QERLRAAVNQ QPLDALKSSS TQTSIPKIQK LKAAKLPSEE ENTTKWLNKA INDLVSSLSK
INFSTEGTEF DKKQIEMIQN LPPLFVFNAR SVIDKEVVPE QEKSAENQPP TSLGINNGNP
VMPPPGFQS
