ID   CATA_VIBPA              Reviewed;         504 AA.
AC   Q87JE8;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Catalase;
DE            EC=1.11.1.6;
DE   Flags: Precursor;
GN   OrderedLocusNames=VPA0305;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to
CC       protect cells from the toxic effects of hydrogen peroxide.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10013};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the catalase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC61648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000032; BAC61648.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_799815.1; NC_004605.1.
DR   RefSeq; WP_021450939.1; NC_004605.1.
DR   AlphaFoldDB; Q87JE8; -.
DR   SMR; Q87JE8; -.
DR   STRING; 223926.28808471; -.
DR   EnsemblBacteria; BAC61648; BAC61648; BAC61648.
DR   GeneID; 1190993; -.
DR   KEGG; vpa:VPA0305; -.
DR   PATRIC; fig|223926.6.peg.3257; -.
DR   eggNOG; COG0753; Bacteria.
DR   HOGENOM; CLU_010645_2_0_6; -.
DR   OMA; HVWPQKQ; -.
DR   Proteomes; UP000002493; Chromosome 2.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; PTHR11465; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
KW   Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Periplasm;
KW   Peroxidase; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..504
FT                   /note="Catalase"
FT                   /id="PRO_0000004690"
FT   ACT_SITE        72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   ACT_SITE        145
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   BINDING         353
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   504 AA;  56585 MW;  A62EA2603CC9AD3C CRC64;
     MQMSKSFLLI TVGLASTSLQ AQTLTRDNGA PVGDNQNSIT AGENGSVLLQ DVHLIQKLQR
     FARERIPERV VHARGTGAHG EFVASGDFSD LTVSAPFTEK GKVTPVFVRF STVIHSKGSP
     ETLRDPRGFA TKFYTEQGNW DLVGNNLPVF FIRDSIKFPD MVHSLKPSPV TNVQDPNRFF
     DFFSHEPSAT HMLTWVYSNL GTPASYRTMD GFGVHAYKWI NQQGDVNYVK FQWKSQQGIK
     SLRPNKVTEM QGKDFNHLTN DLYAAIGRGN YPKWDLYVKV LSPEALSKLD YNGLDATKVW
     LNVPDRKVGT MTLNRLPENF FLETEQSAFA PSNLIPGIEP SEDRLLQGRL FAYADTQLYR
     LGANLFQLPV NRPLTSVNNH NQNGLSNNAQ LSNGDVNYEP SRKLNLAEDN QFKAVETKLV
     GTVQQKAISK PRDFYQAGVL YRSMNEQDRS DLIANLAGDL NKVIDKDIKA TMVSYFYRAD
     KEYGSRLAEA TDTNLSQVKN KAMM