ID   YAD4_SCHPO              Reviewed;         772 AA.
AC   Q09830;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=TBC domain-containing protein C4G8.04;
GN   ORFNames=SPAC4G8.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-395, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
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DR   EMBL; CU329670; CAA91205.1; -; Genomic_DNA.
DR   PIR; T38849; S62481.
DR   RefSeq; NP_593064.1; NM_001018462.2.
DR   AlphaFoldDB; Q09830; -.
DR   SMR; Q09830; -.
DR   BioGRID; 279987; 14.
DR   STRING; 4896.SPAC4G8.04.1; -.
DR   iPTMnet; Q09830; -.
DR   MaxQB; Q09830; -.
DR   PaxDb; Q09830; -.
DR   PRIDE; Q09830; -.
DR   EnsemblFungi; SPAC4G8.04.1; SPAC4G8.04.1:pep; SPAC4G8.04.
DR   GeneID; 2543572; -.
DR   KEGG; spo:SPAC4G8.04; -.
DR   PomBase; SPAC4G8.04; -.
DR   VEuPathDB; FungiDB:SPAC4G8.04; -.
DR   eggNOG; KOG2058; Eukaryota.
DR   HOGENOM; CLU_365307_0_0_1; -.
DR   InParanoid; Q09830; -.
DR   OMA; PVLANTK; -.
DR   Reactome; R-SPO-8854214; TBC/RABGAPs.
DR   PRO; PR:Q09830; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; NAS:PomBase.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..772
FT                   /note="TBC domain-containing protein C4G8.04"
FT                   /id="PRO_0000208059"
FT   DOMAIN          504..693
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          143..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         395
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   772 AA;  86233 MW;  BADC1C8B8EB527E7 CRC64;
     MQPSVSDSSV YLSSAPTKPI ASGSVATGID SMPSKVDITP CDLLENSKSS APLFVECNQE
     SLHSIPGSLH LVPDASIERL IEKHGAVNLL RQLAKDVAER DSFISDLKFH FESREYVFRE
     LLREHGLDPV LANTKLSQRH SASFFPSSQE PSIPENPSSL TGEKPHLYAR IDSAINEPFT
     PSDRLSPSSL VPLLKLPALD HAVSSSSSSD LPSDPNSASY IASSKQKASS LKLTSSLKKF
     YSWTSSSSLQ HTRENLHDST SSLRDHDPSL LSSSKFFRSS PRCSTPSVSS TFVSATSEPE
     VETYSVSTKN SSSNKNLRSS LSKLLSTSNL NNKPLSLSST APSMPSIGSV ELGNMIPKET
     QPPSMRNDWK DYLDNNSKEI LDQFGFLQKR PSHDTPLCPE DIKLNQKQTL SFYESNYGLV
     DDFFGNELDG LNDSPLLLNK KDILLDMKES TRQKNWSLFF QRLYKKYKIT DEDTIGLLGI
     SSIGVKGRHG KKRWHKFREL VKNGVPLCYK AKVWLECSGA YQLHSPGYYE ELLSRTDEVE
     SASVAQIDMD INRTMAKNVF FGGKGPGIPK LRRILVAYSR HNPHIGYCQG MNVIGAFLLL
     LYASEEDAFY MLMSIIENVL PPKYFTPDLM TSRADQLVLK SFVKESLPEI YSHLELLGVD
     LDAISFHWFL SVYTDTLPTN ISFRIFDMLF CDGYVCLFRV ALTILKSLKQ QILACNSSSA
     IYSFLSDLVQ YSFQPDSFIK EAADRWSKLV TEKSIERKRN LAISSLNLAV NY