YADC_ECOLI
ID YADC_ECOLI Reviewed; 412 AA.
AC P31058;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Uncharacterized fimbrial-like protein YadC;
DE Flags: Precursor;
GN Name=yadC; OrderedLocusNames=b0135, JW0131;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8202364; DOI=10.1093/nar/22.9.1637;
RA Fujita N., Mori H., Yura T., Ishihama A.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-
RT 4.1 min (110,917-193,643 bp) region.";
RL Nucleic Acids Res. 22:1637-1639(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-412.
RC STRAIN=K12;
RX PubMed=8096212; DOI=10.1128/jb.175.7.2125-2130.1993;
RA Jones C.E., Brook J.M., Buck D., Abell C., Smith A.G.;
RT "Cloning and sequencing of the Escherichia coli panB gene, which encodes
RT ketopantoate hydroxymethyltransferase, and overexpression of the enzyme.";
RL J. Bacteriol. 175:2125-2130(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 354-412.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA Merkel W.K., Nichols B.P.;
RT "Nucleotide sequence of the Escherichia coli panBCD gene cluster.";
RL Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=20345943; DOI=10.1111/j.1462-2920.2010.02202.x;
RA Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.;
RT "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-
RT usher fimbriae with distinct surface specificities.";
RL Environ. Microbiol. 12:1957-1977(2010).
CC -!- FUNCTION: Part of the yadCKLM-htrE-yadVN fimbrial operon. Could
CC contribute to adhesion to various surfaces in specific environmental
CC niches. {ECO:0000269|PubMed:20345943}.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}.
CC -!- INDUCTION: Repressed by H-NS. {ECO:0000269|PubMed:20345943}.
CC -!- DISRUPTION PHENOTYPE: Deletion of the operon under classical laboratory
CC conditions does not result in any major effect on E.coli capacity to
CC form biofilms compared with the wild-type strain.
CC {ECO:0000269|PubMed:20345943}.
CC -!- MISCELLANEOUS: The operon is cryptic under classical laboratory
CC conditions, but is functional when constitutively expressed.
CC {ECO:0000305|PubMed:20345943}.
CC -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR EMBL; U00096; AAC73246.1; -; Genomic_DNA.
DR EMBL; AP009048; BAB96712.1; -; Genomic_DNA.
DR EMBL; X65538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L17086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; G64736; G64736.
DR RefSeq; NP_414677.1; NC_000913.3.
DR RefSeq; WP_000848455.1; NZ_STEB01000010.1.
DR AlphaFoldDB; P31058; -.
DR SMR; P31058; -.
DR BioGRID; 4262206; 8.
DR DIP; DIP-11181N; -.
DR STRING; 511145.b0135; -.
DR PaxDb; P31058; -.
DR PRIDE; P31058; -.
DR DNASU; 944837; -.
DR EnsemblBacteria; AAC73246; AAC73246; b0135.
DR EnsemblBacteria; BAB96712; BAB96712; BAB96712.
DR GeneID; 944837; -.
DR KEGG; ecj:JW0131; -.
DR KEGG; eco:b0135; -.
DR PATRIC; fig|1411691.4.peg.2146; -.
DR EchoBASE; EB1629; -.
DR eggNOG; COG3539; Bacteria.
DR HOGENOM; CLU_053820_1_0_6; -.
DR OMA; APMSIEH; -.
DR BioCyc; EcoCyc:EG11678-MON; -.
DR PHI-base; PHI:6567; -.
DR PRO; PR:P31058; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009289; C:pilus; IMP:EcoCyc.
DR GO; GO:0007155; P:cell adhesion; IMP:EcoCyc.
DR GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IMP:EcoCyc.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:EcoCyc.
DR GO; GO:0046677; P:response to antibiotic; IMP:EcoCyc.
DR Gene3D; 2.60.40.1090; -; 1.
DR InterPro; IPR000259; Adhesion_dom_fimbrial.
DR InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR017014; Fimbrial-like_YadC.
DR Pfam; PF00419; Fimbrial; 1.
DR PIRSF; PIRSF033053; UCP033503_fimbr; 1.
DR SUPFAM; SSF49401; SSF49401; 1.
PE 2: Evidence at transcript level;
KW Fimbrium; Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..412
FT /note="Uncharacterized fimbrial-like protein YadC"
FT /id="PRO_0000009253"
FT CONFLICT 206..207
FT /note="LN -> VT (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 210..211
FT /note="VQ -> IK (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 226..245
FT /note="SPGTKVVDHSNHIYVNFTLN -> GAGQGINEHSYFIKIDFDLL (in
FT Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 251
FT /note="L -> N (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 257..262
FT /note="SILTGP -> AMLSGT (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="N -> T (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="R -> K (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 276..280
FT /note="SGTIK -> AEQKR (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="S -> T (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="I -> V (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 299
FT /note="R -> T (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 307..308
FT /note="TG -> ST (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 313..315
FT /note="QNT -> ETG (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 325..326
FT /note="ST -> ND (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="T -> S (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 358
FT /note="I -> K (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 361..363
FT /note="ETE -> DPRGK (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 367..368
FT /note="SD -> TG (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 373..380
FT /note="NQGNGTSQ -> DQDTGITY (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 389
FT /note="K -> Q (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="N -> T (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="A -> P (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="P -> A (in Ref. 4; X65538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 412 AA; 44899 MW; 3945450AD85EB5BE CRC64;
MKTIFRYILF LALYSCCNTV SAYTSFIVGN NAGVDNYRGP STAAQMTFNY TSTASNLVFY
KPTQLGPTGV KMYWSYLDTG TGGGILYCNT SGRANPGPIT IENAMVYSGK DYGGHKLFNT
SVPGLYYTML ISRVWSAYDT ITDIQSPGIY IGDPSNQEFF FSVTDSDLQT KGCNKADDYD
KFWAIGGIVH NITVEFYTDT NFDPTLNQQV QLSSSSNYLY SFKAYSPGTK VVDHSNHIYV
NFTLNNVKLT LPTCFTSILT GPSVNGSTVR MGEYSSGTIK NGASPVPFDI SLQNCIRVRN
IETKLVTGKV GTQNTQLLGN TLTGSTAAKG VGVLIEGLAT SKNPLMTLKP NDTNSVYIDY
ETEDDTSDGV YPNQGNGTSQ PLHFQATLKQ DGNIAIEPGE FKATSTFQVT YP
