YADH_ECOLI
ID YADH_ECOLI Reviewed; 256 AA.
AC P0AFN6; P36880; P75657; Q8KMY9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Inner membrane transport permease YadH;
GN Name=yadH; OrderedLocusNames=b0128, JW0124;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8202364; DOI=10.1093/nar/22.9.1637;
RA Fujita N., Mori H., Yura T., Ishihama A.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-
RT 4.1 min (110,917-193,643 bp) region.";
RL Nucleic Acids Res. 22:1637-1639(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ABC-2 integral membrane protein family.
CC {ECO:0000305}.
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DR EMBL; U00096; AAC73239.1; -; Genomic_DNA.
DR EMBL; AP009048; BAB96705.2; -; Genomic_DNA.
DR PIR; H64735; H64735.
DR RefSeq; NP_414670.1; NC_000913.3.
DR RefSeq; WP_000972203.1; NZ_STEB01000010.1.
DR AlphaFoldDB; P0AFN6; -.
DR SMR; P0AFN6; -.
DR BioGRID; 4259734; 47.
DR STRING; 511145.b0128; -.
DR TCDB; 3.A.1.105.17; the atp-binding cassette (abc) superfamily.
DR PaxDb; P0AFN6; -.
DR PRIDE; P0AFN6; -.
DR EnsemblBacteria; AAC73239; AAC73239; b0128.
DR EnsemblBacteria; BAB96705; BAB96705; BAB96705.
DR GeneID; 66671583; -.
DR GeneID; 944836; -.
DR KEGG; ecj:JW0124; -.
DR KEGG; eco:b0128; -.
DR PATRIC; fig|1411691.4.peg.2154; -.
DR EchoBASE; EB2226; -.
DR eggNOG; COG0842; Bacteria.
DR HOGENOM; CLU_039483_3_0_6; -.
DR InParanoid; P0AFN6; -.
DR OMA; HSLPPFW; -.
DR PhylomeDB; P0AFN6; -.
DR BioCyc; EcoCyc:YADH-MON; -.
DR PRO; PR:P0AFN6; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR000412; ABC_2_transport.
DR Pfam; PF01061; ABC2_membrane; 1.
DR PIRSF; PIRSF006648; DrrB; 1.
DR PRINTS; PR00164; ABC2TRNSPORT.
DR PROSITE; PS51012; ABC_TM2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..256
FT /note="Inner membrane transport permease YadH"
FT /id="PRO_0000182998"
FT TOPO_DOM 1..22
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..94
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..223
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..251
FT /note="ABC transmembrane type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
FT CONFLICT 214
FT /note="F -> L (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 256 AA; 28516 MW; 2AE10E6CB143F708 CRC64;
MMHLYWVALK SIWAKEIHRF MRIWVQTLVP PVITMTLYFI IFGNLIGSRI GDMHGFSYMQ
FIVPGLIMMS VITNAYANVA SSFFGAKFQR NIEELLVAPV PTHVIIAGYV GGGVARGLFV
GILVTAISLF FVPFQVHSWV FVALTLVLTA VLFSLAGLLN GVFAKTFDDI SLVPTFVLTP
LTYLGGVFYS LTLLPPFWQG LSHLNPIVYM ISGFRYGFLG INDVPLVTTF GVLVVFIVAF
YLICWSLIQR GRGLRS
