ID   YAE1_ASHGO              Reviewed;         144 AA.
AC   Q753A3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Protein YAE1;
GN   Name=YAE1; OrderedLocusNames=AFR421C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: The complex LTO1:YAE1 may function as a target specific
CC       adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur
CC       protein assembly (CIA) complex machinery. May be required for
CC       biogenesis of the large ribosomal subunit and initiation of
CC       translation. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBUNIT: May form a complex with LTO1. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47118}. Nucleus
CC       {ECO:0000250|UniProtKB:P47118}.
CC   -!- SIMILARITY: Belongs to the YAE1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53792.2; -; Genomic_DNA.
DR   RefSeq; NP_985968.2; NM_211323.2.
DR   AlphaFoldDB; Q753A3; -.
DR   STRING; 33169.AAS53792; -.
DR   EnsemblFungi; AAS53792; AAS53792; AGOS_AFR421C.
DR   GeneID; 4622241; -.
DR   KEGG; ago:AGOS_AFR421C; -.
DR   eggNOG; KOG4774; Eukaryota.
DR   HOGENOM; CLU_066684_2_0_1; -.
DR   InParanoid; Q753A3; -.
DR   OMA; DESYHEL; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0097361; C:CIA complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0062092; C:Yae1-Lto1 complex; IEA:EnsemblFungi.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR   GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; ISS:UniProtKB.
DR   InterPro; IPR019191; Essential_protein_Yae1_N.
DR   InterPro; IPR038881; Yae1-like.
DR   PANTHER; PTHR18829; PTHR18829; 1.
DR   Pfam; PF09811; Yae1_N; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..144
FT                   /note="Protein YAE1"
FT                   /id="PRO_0000324417"
FT   REGION          38..78
FT                   /note="deca-GX3 motif; required for interaction with LTO1"
FT                   /evidence="ECO:0000250|UniProtKB:P47118"
SQ   SEQUENCE   144 AA;  16193 MW;  62AF82F02060D017 CRC64;
     MSCEDDWLNT SDDEEKHGVF GGGSLELQKL ERTHRNRGYR DGISSAKEEN LQEGFDMKFP
     EGSRLGFQVG EVIGKLQTLD SLFGAQDSEL RSDYKEALAQ LQISRVLTHA NFSEQMDATE
     ALSSLLARWE GALVKYTSRY IPNV