YAE1_ASPCL
ID YAE1_ASPCL Reviewed; 226 AA.
AC A1CJJ9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Protein yae1;
GN Name=yae1; ORFNames=ACLA_035260;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: The complex LTO1:YAE1 may function as a target specific
CC adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur
CC protein assembly (CIA) complex machinery. May be required for
CC biogenesis of the large ribosomal subunit and initiation of
CC translation. {ECO:0000250|UniProtKB:Q9NRH1}.
CC -!- SUBUNIT: May form a complex with LTO1. {ECO:0000250|UniProtKB:Q9NRH1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47118}. Nucleus
CC {ECO:0000250|UniProtKB:P47118}.
CC -!- SIMILARITY: Belongs to the YAE1 family. {ECO:0000305}.
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DR EMBL; DS027056; EAW09323.1; -; Genomic_DNA.
DR RefSeq; XP_001270749.1; XM_001270748.1.
DR AlphaFoldDB; A1CJJ9; -.
DR STRING; 5057.CADACLAP00003351; -.
DR EnsemblFungi; EAW09323; EAW09323; ACLA_035260.
DR GeneID; 4703139; -.
DR KEGG; act:ACLA_035260; -.
DR VEuPathDB; FungiDB:ACLA_035260; -.
DR eggNOG; KOG4774; Eukaryota.
DR HOGENOM; CLU_066684_1_1_1; -.
DR OMA; GYRDGTS; -.
DR OrthoDB; 1192442at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; ISS:UniProtKB.
DR InterPro; IPR019191; Essential_protein_Yae1_N.
DR InterPro; IPR038881; Yae1-like.
DR PANTHER; PTHR18829; PTHR18829; 1.
DR Pfam; PF09811; Yae1_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..226
FT /note="Protein yae1"
FT /id="PRO_0000324418"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..97
FT /note="deca-GX3 motif; required for interaction with LTO1"
FT /evidence="ECO:0000250|UniProtKB:P47118"
FT REGION 105..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 24864 MW; 4F153B1E5D3659C9 CRC64;
MATNTHNSLD DIFGSSPPHE HEHEHHQHQD LHPQPPPTQA PEPSDLPSLR RQHVTAGYRD
GISAAKGAQV QRGFDAGFPV GAQLGMRAGT VLGILEGLVR GYEGRGGVKK PAQLQRGKTA
SSATEGQGEG DAEAAERKAR REEILRLYTR AVKELDVRAV FSGVDGAFAT EGDEEEKPEI
LLRQKGDGVV SRWEERVRVA HWEENMDALE PRDKEEEEEK ALSEQS
