ID   YAE1_ASPFU              Reviewed;         213 AA.
AC   Q4WWW5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Protein yae1;
GN   Name=yae1; ORFNames=AFUA_3G07330;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: The complex LTO1:YAE1 may function as a target specific
CC       adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur
CC       protein assembly (CIA) complex machinery. May be required for
CC       biogenesis of the large ribosomal subunit and initiation of
CC       translation. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBUNIT: May form a complex with LTO1. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47118}. Nucleus
CC       {ECO:0000250|UniProtKB:P47118}.
CC   -!- SIMILARITY: Belongs to the YAE1 family. {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92838.1; -; Genomic_DNA.
DR   RefSeq; XP_754876.1; XM_749783.1.
DR   AlphaFoldDB; Q4WWW5; -.
DR   STRING; 746128.CADAFUBP00004092; -.
DR   EnsemblFungi; EAL92838; EAL92838; AFUA_3G07330.
DR   GeneID; 3512109; -.
DR   KEGG; afm:AFUA_3G07330; -.
DR   VEuPathDB; FungiDB:Afu3g07330; -.
DR   eggNOG; KOG4774; Eukaryota.
DR   HOGENOM; CLU_066684_1_1_1; -.
DR   InParanoid; Q4WWW5; -.
DR   OMA; GYRDGTS; -.
DR   OrthoDB; 1192442at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; ISS:UniProtKB.
DR   InterPro; IPR019191; Essential_protein_Yae1_N.
DR   InterPro; IPR038881; Yae1-like.
DR   PANTHER; PTHR18829; PTHR18829; 1.
DR   Pfam; PF09811; Yae1_N; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Protein yae1"
FT                   /id="PRO_0000324419"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          49..89
FT                   /note="deca-GX3 motif; required for interaction with LTO1"
FT                   /evidence="ECO:0000250|UniProtKB:P47118"
FT   REGION          102..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   213 AA;  23441 MW;  8CFCEFEF8FBB432D CRC64;
     MTSPQTNSLD DIFGSSPPHE GEKFSQQASI EAPEPSDLPS LRRQHVTAGY RDGVSAAKGE
     HVQHGFDAGF PIGAQLGMRA GTVIGIIEGL LRGFESPTAS RAVKKPLQRK EEGQGVETDE
     AEAARQAKRE QLLRLYQKAV KELEVRSVFA GSEEESTRDN GGQEKPEVVL RRKGDAVISQ
     WEEQVRVAHW EENMAALEPK EDEKRASTPT EQI