ID   YAE1_CANAL              Reviewed;         180 AA.
AC   Q9P840; A0A1D8PQQ1; Q5AFN1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein YAE1;
GN   Name=YAE1; OrderedLocusNames=CAALFM_C700800CA;
GN   ORFNames=CaJ7.0095, CaO19.7037;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   De Backer M.D., Logghe M., Viaene J., Loonen I., Vandoninck S.,
RA   de Hoogt R., Nelissen B., Dewaele S., Simons F., Verhasselt P.,
RA   Contreras R., Luyten W.H.M.L.;
RT   "A novel method for systematic identification of genes required for growth
RT   of Candida albicans.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA   Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA   Mikami Y.;
RT   "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT   syntenic analysis against the Saccharomyces cerevisiae genome.";
RL   Genetics 170:1525-1537(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: The complex LTO1:YAE1 may function as a target specific
CC       adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur
CC       protein assembly (CIA) complex machinery. May be required for
CC       biogenesis of the large ribosomal subunit and initiation of
CC       translation. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBUNIT: May form a complex with LTO1. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47118}. Nucleus
CC       {ECO:0000250|UniProtKB:P47118}.
CC   -!- SIMILARITY: Belongs to the YAE1 family. {ECO:0000305}.
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DR   EMBL; AJ390499; CAB77639.1; -; Genomic_DNA.
DR   EMBL; AP006852; BAE44607.1; -; Genomic_DNA.
DR   EMBL; CP017629; AOW30456.1; -; Genomic_DNA.
DR   RefSeq; XP_720330.1; XM_715237.1.
DR   AlphaFoldDB; Q9P840; -.
DR   STRING; 237561.Q9P840; -.
DR   PRIDE; Q9P840; -.
DR   GeneID; 3637941; -.
DR   KEGG; cal:CAALFM_C700800CA; -.
DR   CGD; CAL0000178940; YAE1.
DR   VEuPathDB; FungiDB:C7_00800C_A; -.
DR   eggNOG; KOG4774; Eukaryota.
DR   HOGENOM; CLU_066684_2_0_1; -.
DR   InParanoid; Q9P840; -.
DR   OMA; DESYHEL; -.
DR   OrthoDB; 1192442at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; ISS:UniProtKB.
DR   InterPro; IPR019191; Essential_protein_Yae1_N.
DR   InterPro; IPR038881; Yae1-like.
DR   PANTHER; PTHR18829; PTHR18829; 1.
DR   Pfam; PF09811; Yae1_N; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..180
FT                   /note="Protein YAE1"
FT                   /id="PRO_0000324423"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..108
FT                   /note="deca-GX3 motif; required for interaction with LTO1"
FT                   /evidence="ECO:0000250|UniProtKB:P47118"
FT   REGION          112..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   180 AA;  20240 MW;  EC98B8E63C1676C7 CRC64;
     MTCQEDCSCK NNEAPTTKTT ATTTNVGDGP GPGPIPGNND DDDDDIWSDD DTKLIPENDI
     IRSHYKKGYV DGITQAKESS LQQGFDDGYP EGAKLGIKVG EILANLINQC KDRNRQGDDD
     DDDDDEQSVR FNEAKKELNI VNVLKKSYFD EDLNLKKSND NKETDESYHE LINKWENEMK