ID   YAE1_PICST              Reviewed;         143 AA.
AC   A3LWJ7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Protein YAE1;
GN   Name=YAE1; ORFNames=PICST_32496;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: The complex LTO1:YAE1 may function as a target specific
CC       adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur
CC       protein assembly (CIA) complex machinery. May be required for
CC       biogenesis of the large ribosomal subunit and initiation of
CC       translation. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBUNIT: May form a complex with LTO1. {ECO:0000250|UniProtKB:Q9NRH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47118}. Nucleus
CC       {ECO:0000250|UniProtKB:P47118}.
CC   -!- SIMILARITY: Belongs to the YAE1 family. {ECO:0000305}.
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DR   EMBL; CP000499; ABN66984.2; -; Genomic_DNA.
DR   RefSeq; XP_001385013.2; XM_001384976.1.
DR   AlphaFoldDB; A3LWJ7; -.
DR   STRING; 4924.XP_001385013.2; -.
DR   EnsemblFungi; ABN66984; ABN66984; PICST_32496.
DR   GeneID; 4839203; -.
DR   KEGG; pic:PICST_32496; -.
DR   eggNOG; KOG4774; Eukaryota.
DR   HOGENOM; CLU_066684_2_0_1; -.
DR   InParanoid; A3LWJ7; -.
DR   OMA; DESYHEL; -.
DR   OrthoDB; 1192442at2759; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; ISS:UniProtKB.
DR   InterPro; IPR019191; Essential_protein_Yae1_N.
DR   Pfam; PF09811; Yae1_N; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..143
FT                   /note="Protein YAE1"
FT                   /id="PRO_0000324433"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..88
FT                   /note="deca-GX3 motif; required for interaction with LTO1"
FT                   /evidence="ECO:0000250|UniProtKB:P47118"
SQ   SEQUENCE   143 AA;  15923 MW;  91D098D83AA45A44 CRC64;
     MGCSNCQPEI KTSLHSKDSN DFEDDVWGDD DVYVDANADV KRAHQKQGYL DGLASAQESS
     LQSGFDKAFS DGARMGAAVG KILGELRALG ESESFYQATK ELNIAKIMDK KYFDSELKIQ
     KNHEVIYKWQ KIVAQHLEDA TKA