ID   YAE3_SCHPO              Reviewed;         472 AA.
AC   Q09844;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=TBC domain-containing protein C23D3.03c;
GN   ORFNames=SPAC23D3.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
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DR   EMBL; CU329670; CAA91238.1; -; Genomic_DNA.
DR   PIR; S62494; S62494.
DR   RefSeq; NP_594541.1; NM_001019970.2.
DR   AlphaFoldDB; Q09844; -.
DR   SMR; Q09844; -.
DR   BioGRID; 277984; 2.
DR   STRING; 4896.SPAC23D3.03c.1; -.
DR   iPTMnet; Q09844; -.
DR   MaxQB; Q09844; -.
DR   PaxDb; Q09844; -.
DR   EnsemblFungi; SPAC23D3.03c.1; SPAC23D3.03c.1:pep; SPAC23D3.03c.
DR   GeneID; 2541482; -.
DR   KEGG; spo:SPAC23D3.03c; -.
DR   PomBase; SPAC23D3.03c; -.
DR   VEuPathDB; FungiDB:SPAC23D3.03c; -.
DR   eggNOG; KOG2223; Eukaryota.
DR   HOGENOM; CLU_575102_0_0_1; -.
DR   InParanoid; Q09844; -.
DR   OMA; KYLNAMD; -.
DR   PhylomeDB; Q09844; -.
DR   Reactome; R-SPO-8854214; TBC/RABGAPs.
DR   PRO; PR:Q09844; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; NAS:PomBase.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..472
FT                   /note="TBC domain-containing protein C23D3.03c"
FT                   /id="PRO_0000208060"
FT   DOMAIN          215..418
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   472 AA;  54319 MW;  156C417C8873638E CRC64;
     MESLESVDAS SGSVGSYMSK SVRKHWWSRK GYHPTGSSKN GSRLKISSDE NFQDELVVLD
     DAFLCNVPLE LPSTSNAQKT AAESFSKLSP QDQLLSLQLN NVQESVFQQS TFNLPDALLD
     PGPASKEKQA VLSIGRPSWL PPKSKEEEKK HMREFEQIKK SAMRYDRQKQ KEKIKMVEQK
     NKRNLYLVNV WEREILRNWP DALKSSRYAG IWRQGIPSRV RGRVWEKAIG NNLKLDYQSF
     FNARANAQKR EAAEKAEQMN NANQFREDVC ALELDLQSTM PHYSLFHTEG PLRRDLIGLL
     RAYSYYRFDT SYIPGTSFIG ALLLLNMNLT SAFNCLANLL DKPFLQAVYT QDTSSLKSFY
     QTFLDTLKKN EPELATHLLI KLELVPDDFV YPLLRKLFIP MVSPEIASRI LDCYVFEEDS
     FFIQLLMAVF KLLKPKLLVD DSRLVLSALL FENWDLGPED EFMHFVYDIS LS