ID   YAFD_ECOLI              Reviewed;         266 AA.
AC   P0A8U2; P30865; P75671;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=UPF0294 protein YafD;
GN   Name=yafD; OrderedLocusNames=b0209, JW5017;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Nishimura K., Komine Y., Miyamoto K., Kitabatake M., Mathunaga F.,
RA   Hisano T., Miki T., Inokuchi H.;
RL   Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T.,
RA   Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S.,
RA   Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.;
RT   "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0
RT   - 6.0 min (189,987 - 281,416bp) region.";
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-259.
RC   STRAIN=K12;
RX   PubMed=1663890; DOI=10.1016/0378-1097(91)90355-e;
RA   Kajie S., Ideta R., Yamato I., Anraku Y.;
RT   "Molecular cloning and DNA sequence of dniR, a gene affecting anaerobic
RT   expression of the Escherichia coli hexaheme nitrite reductase.";
RL   FEMS Microbiol. Lett. 67:205-211(1991).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0294 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB08631.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA02172.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D12650; BAA02172.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U70214; AAB08631.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC73314.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA77880.2; -; Genomic_DNA.
DR   EMBL; X60739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; C64745; C64745.
DR   RefSeq; NP_414745.1; NC_000913.3.
DR   RefSeq; WP_001230983.1; NZ_STEB01000020.1.
DR   RefSeq; WP_001300451.1; NZ_JACEFS010000039.1.
DR   AlphaFoldDB; P0A8U2; -.
DR   SMR; P0A8U2; -.
DR   BioGRID; 4261255; 229.
DR   DIP; DIP-47877N; -.
DR   STRING; 511145.b0209; -.
DR   jPOST; P0A8U2; -.
DR   PaxDb; P0A8U2; -.
DR   PRIDE; P0A8U2; -.
DR   EnsemblBacteria; AAC73314; AAC73314; b0209.
DR   EnsemblBacteria; BAA77880; BAA77880; BAA77880.
DR   GeneID; 66671501; -.
DR   GeneID; 946286; -.
DR   KEGG; ecj:JW5017; -.
DR   KEGG; eco:b0209; -.
DR   PATRIC; fig|511145.12.peg.211; -.
DR   EchoBASE; EB1603; -.
DR   eggNOG; COG3021; Bacteria.
DR   HOGENOM; CLU_083563_0_0_6; -.
DR   InParanoid; P0A8U2; -.
DR   OMA; HAINFSF; -.
DR   PhylomeDB; P0A8U2; -.
DR   BioCyc; EcoCyc:EG11650-MON; -.
DR   PRO; PR:P0A8U2; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.60.10.10; -; 1.
DR   HAMAP; MF_01119; UPF0294; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR022958; UPF0294.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..266
FT                   /note="UPF0294 protein YafD"
FT                   /id="PRO_0000074637"
FT   CONFLICT        112
FT                   /note="T -> S (in Ref. 6)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223
FT                   /note="R -> G (in Ref. 6)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   266 AA;  29992 MW;  5F5AD2B0C4CE5794 CRC64;
     MRKNTYAMRY VAGQPAERIL PPGSFASIGQ ALPPGEPLST EERIRILVWN IYKQQRAEWL
     SVLKNYGKDA HLVLLQEAQT TPELVQFATA NYLAADQVPA FVLPQHPSGV MTLSAAHPVY
     CCPLREREPI LRLAKSALVT VYPLPDTRLL MVVNIHAVNF SLGVDVYSKQ LLPIGDQIAH
     HSGPVIMAGD FNAWSRRRMN ALYRFAREMS LRQVRFTDDQ RRRAFGRPLD FVFYRGLNVS
     EASVLVTRAS DHNPLLVEFS PGKPDK