ID   YAFQ_HAEIN              Reviewed;         102 AA.
AC   P44041;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative toxin YafQ;
GN   Name=yafQ {ECO:0000305}; Synonyms=relE {ECO:0000303|PubMed:15718296};
GN   OrderedLocusNames=HI_0711;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Its
CC       cognate antitoxin is RelB (By similarity).
CC       {ECO:0000250|UniProtKB:Q47149}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. YafQ subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22368.1; -; Genomic_DNA.
DR   PIR; E64012; E64012.
DR   RefSeq; NP_438869.1; NC_000907.1.
DR   RefSeq; WP_005694595.1; NC_000907.1.
DR   AlphaFoldDB; P44041; -.
DR   SMR; P44041; -.
DR   STRING; 71421.HI_0711; -.
DR   EnsemblBacteria; AAC22368; AAC22368; HI_0711.
DR   KEGG; hin:HI_0711; -.
DR   PATRIC; fig|71421.8.peg.742; -.
DR   eggNOG; COG3041; Bacteria.
DR   HOGENOM; CLU_161929_4_1_6; -.
DR   OMA; ENYQDHA; -.
DR   PhylomeDB; P44041; -.
DR   BioCyc; HINF71421:G1GJ1-745-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0006415; P:translational termination; IBA:GO_Central.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR004386; Toxin_YafQ-like.
DR   PANTHER; PTHR40588; PTHR40588; 1.
DR   Pfam; PF15738; YafQ_toxin; 1.
DR   PIRSF; PIRSF006156; YafQ; 1.
DR   SUPFAM; SSF143011; SSF143011; 1.
DR   TIGRFAMs; TIGR02385; RelE_StbE; 1.
DR   TIGRFAMs; TIGR00053; TIGR00053; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..102
FT                   /note="Putative toxin YafQ"
FT                   /id="PRO_0000168541"
SQ   SEQUENCE   102 AA;  11908 MW;  410DBEAD23CD5892 CRC64;
     MSEEKPLKVS YSKQFVRDLT DLAKRSPNVL IGSKYITAIH CLLNRLPLPE NYQDHALVGE
     WKGYRDCHIQ GDLVLIYQYV IQDEFDELKF SRLNIHSQTA LK