ID   YAGB_ECOLI              Reviewed;         116 AA.
AC   P37008; A0A385XJ59; P77583; Q2MCF4;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Orphan antitoxin YagB;
GN   Name=yagB; OrderedLocusNames=b0266, JW0259;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8113168; DOI=10.1128/jb.176.5.1297-1302.1994;
RA   Volkert M.R., Loewen P.C., Switala J., Crowley D., Conley M.;
RT   "The delta (argF-lacZ)205(U169) deletion greatly enhances resistance to
RT   hydrogen peroxide in stationary-phase Escherichia coli.";
RL   J. Bacteriol. 176:1297-1302(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T.,
RA   Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S.,
RA   Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.;
RT   "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0
RT   - 6.0 min (189,987 - 281,416bp) region.";
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [6]
RP   IDENTIFICATION.
RA   Rudd K.E.;
RL   Unpublished observations (MAR-1996).
CC   -!- FUNCTION: Putative antitoxin component of a type IV toxin-antitoxin
CC       (TA) system; its cognate toxin is unknown. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Encoded by the CP4-6 prophage. An insertion element
CC       (ISX') seems to have deleted the end of yagB, fusing it to 13 insX'
CC       codons to make a 116 fusion pseudogene that may be expressed. The
CC       cognate toxin appears to have been deleted at the same time.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CbeA/YafW/YfjZ antitoxin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB08687.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=L20943; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L20943; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   EMBL; U70214; AAB08687.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AYC08170.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76052.1; -; Genomic_DNA.
DR   PIR; B64752; B64752.
DR   RefSeq; WP_001030800.1; NZ_LN832404.1.
DR   AlphaFoldDB; P37008; -.
DR   SMR; P37008; -.
DR   BioGRID; 4262794; 8.
DR   IntAct; P37008; 4.
DR   STRING; 316407.85674410; -.
DR   PRIDE; P37008; -.
DR   EnsemblBacteria; AYC08170; AYC08170; b0266.
DR   EnsemblBacteria; BAE76052; BAE76052; BAE76052.
DR   KEGG; ecj:JW0259; -.
DR   PATRIC; fig|83333.103.peg.1021; -.
DR   EchoBASE; EB2243; -.
DR   eggNOG; ENOG5032A8G; Bacteria.
DR   HOGENOM; CLU_144696_0_0_6; -.
DR   OMA; NPRHPHC; -.
DR   PhylomeDB; P37008; -.
DR   BioCyc; EcoCyc:EG12339-MON; -.
DR   PRO; PR:P37008; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0051495; P:positive regulation of cytoskeleton organization; IEA:InterPro.
DR   InterPro; IPR009320; Antitoxin_CbeA.
DR   InterPro; IPR038025; CbeA_sf.
DR   Pfam; PF06154; CbeA_antitoxin; 1.
DR   SUPFAM; SSF143737; SSF143737; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..116
FT                   /note="Orphan antitoxin YagB"
FT                   /id="PRO_0000168555"
SQ   SEQUENCE   116 AA;  13184 MW;  A87EC473D837685E CRC64;
     MNKDSTQTWG LKRDITPCFG ARLVQEGHRL HFLADRAGFT GSFSEVQTLQ LDEAFPHFVA
     HLELMLLSCE LNPRYAHCVT LYRNGLTGEA DTLGSHGYVY IAILNRHGFN RHLRVI