YAJ3_YEAST
ID YAJ3_YEAST Reviewed; 179 AA.
AC D6VPM8; P39546; Q70DI0; Q70DI1; Q70DI5; Q70DI6; Q70DI7; Q70DI8; Q70DJ1;
AC Q70DJ2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Putative DUP240 protein YAR023C;
GN OrderedLocusNames=YAR023C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=15087486; DOI=10.1093/nar/gkh529;
RA Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S.,
RA Souciet J.-L.;
RT "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and
RT implication of recombination in phylogeny.";
RL Nucleic Acids Res. 32:2069-2078(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RA Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B.,
RA Kaback D.B., Clark M.W.;
RT "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52
RT Kbp CDC15-FLO1-PHO11-YAR074 region.";
RL Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA Storms R.K.;
RT "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN [4]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 20 AND 46.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP IDENTIFICATION OF FRAMESHIFT.
RX PubMed=15917500; DOI=10.1093/molbev/msi170;
RA Wirth B., Louis V.L., Potier S., Souciet J.-L., Despons L.;
RT "Paleogenomics or the search for remnant duplicated copies of the yeast
RT DUP240 gene family in intergenic areas.";
RL Mol. Biol. Evol. 22:1764-1771(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Members of the DUP240 multigene family are specific to
CC S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show
CC no obvious alterations in mating, sporulation and cell growth.
CC -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. This is the C-terminal
CC part of a DUP240 protein in strain S288c due to a naturally occurring
CC frameshift at position 8 compared to other strains. A complete sequence
CC for YAR023C can be found in other strain backgrounds (AC P0CI38).
CC {ECO:0000305}.
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DR EMBL; AJ585534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L28920; AAC09488.1; -; Genomic_DNA.
DR EMBL; BK006935; DAA06998.2; -; Genomic_DNA.
DR PIR; S53469; S53469.
DR RefSeq; NP_009413.2; NM_001178220.2.
DR AlphaFoldDB; D6VPM8; -.
DR BioGRID; 31803; 30.
DR STRING; 4932.YAR023C; -.
DR PaxDb; D6VPM8; -.
DR EnsemblFungi; YAR023C_mRNA; YAR023C; YAR023C.
DR GeneID; 851276; -.
DR KEGG; sce:YAR023C; -.
DR SGD; S000000074; YAR023C.
DR VEuPathDB; FungiDB:YAR023C; -.
DR eggNOG; ENOG502SSNW; Eukaryota.
DR GeneTree; ENSGT00940000176285; -.
DR HOGENOM; CLU_081384_2_0_1; -.
DR InParanoid; D6VPM8; -.
DR OMA; HAVREYW; -.
DR BioCyc; YEAST:G3O-28877-MON; -.
DR Proteomes; UP000002311; Chromosome I.
DR RNAct; D6VPM8; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR001142; DUP/COS.
DR Pfam; PF00674; DUP; 1.
PE 5: Uncertain;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..179
FT /note="Putative DUP240 protein YAR023C"
FT /id="PRO_0000402276"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 20
FT /note="F -> V (in Ref. 1; AJ585534, 2 and 3; AAC09488)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="F -> I (in Ref. 1; AJ585534, 2; no nucleotide entry
FT and 3; AAC09488)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 179 AA; 20703 MW; AB45C98ABAB06346 CRC64;
MINFLLFVLT ILATLTNIWF SGVLSPAMVI RICLGGSMVV LQIWSFSRPI SNETFRTKLL
LEVITHRPSI AGKEWKTITY NMNQYLFKAG LWKTPYHFFC EHQCYEFFKD LIKGKYPDVQ
WDTANTQPFI SVPENQAATQ NSDVEPTVKW CLFKAAEIQA HAVREYWQSQ YPDVGIPAI
