YAJ3_YEASX
ID YAJ3_YEASX Reviewed; 240 AA.
AC P0CI38; P39546; Q70DI0; Q70DI1; Q70DI5; Q70DI6; Q70DI7; Q70DI8; Q70DJ1;
AC Q70DJ2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=DUP240 protein YAR023C;
OS Saccharomyces cerevisiae (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=4932;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-11; ILE-18; PHE-67;
RP LEU-70; ASN-78; LEU-81; GLN-92; GLY-99; LEU-100; LEU-106; ASN-119 AND
RP PRO-203.
RC STRAIN=CBS 5287 / CLIB 219, CLIB 388, CLIB 410, CLIB 413, CLIB 556,
RC CLIB 630, CLIB 95,
RC Diastaticus / ATCC 13007 / CBS 1782 / CLIB 382 / NBRC 1046 / NRRL Y-2416,
RC K1, R12, R13, Sigma 1278B, YIIc12, and YIIc17;
RX PubMed=15087486; DOI=10.1093/nar/gkh529;
RA Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S.,
RA Souciet J.-L.;
RT "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and
RT implication of recombination in phylogeny.";
RL Nucleic Acids Res. 32:2069-2078(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND REVISION OF GENE MODEL.
RX PubMed=15917500; DOI=10.1093/molbev/msi170;
RA Wirth B., Louis V.L., Potier S., Souciet J.-L., Despons L.;
RT "Paleogenomics or the search for remnant duplicated copies of the yeast
RT DUP240 gene family in intergenic areas.";
RL Mol. Biol. Evol. 22:1764-1771(2005).
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=12101299; DOI=10.1099/00221287-148-7-2111;
RA Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L.,
RA Jauniaux J.-C.;
RT "Functional analysis of the Saccharomyces cerevisiae DUP240 multigene
RT family reveals membrane-associated proteins that are not essential for cell
RT viability.";
RL Microbiology 148:2111-2123(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Members of the DUP240 multigene family are
CC specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240
CC proteins show no obvious alterations in mating, sporulation and cell
CC growth. {ECO:0000269|PubMed:12101299}.
CC -!- MISCELLANEOUS: Has been shown to be a pseudogene in S288c, CLIB 95,
CC CLIB 388, R12, YIIc12 and YIIc17, due to a naturally occurring
CC frameshift at position 8 in these strains. The sequence shown is from
CC strain Sigma 1278B, the closest phylogenetic relative of S288c.
CC -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
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DR EMBL; AJ585532; CAE52052.2; -; Genomic_DNA.
DR EMBL; AJ585533; CAE52053.2; -; Genomic_DNA.
DR EMBL; AJ585535; CAE52055.2; -; Genomic_DNA.
DR EMBL; AJ585536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ585537; CAE52057.2; -; Genomic_DNA.
DR EMBL; AJ585538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ585539; CAE52059.2; -; Genomic_DNA.
DR EMBL; AJ585540; CAE52060.2; -; Genomic_DNA.
DR EMBL; AJ585541; CAE52061.2; -; Genomic_DNA.
DR EMBL; AJ585542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ585543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ585544; CAE52064.2; -; Genomic_DNA.
DR EMBL; AJ585545; CAE52065.2; -; Genomic_DNA.
DR EMBL; AJ585546; CAE52066.2; -; Genomic_DNA.
DR EMBL; AJ585547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ585548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0CI38; -.
DR IntAct; P0CI38; 3.
DR MINT; P0CI38; -.
DR VEuPathDB; FungiDB:YAR023C; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR001142; DUP/COS.
DR Pfam; PF00674; DUP; 1.
PE 3: Inferred from homology;
KW Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..240
FT /note="DUP240 protein YAR023C"
FT /id="PRO_0000207527"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 11
FT /note="A -> V (in strain: CLIB 219, CLIB 410 and CLIB 413)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 18
FT /note="S -> I (in strain: CLIB 219, CLIB 410 and CLIB 413)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 67
FT /note="L -> F (in strain: CLIB 382, CLIB 556 and CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 70
FT /note="V -> L (in strain: CLIB 382, CLIB 556 and CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 78
FT /note="D -> N (in strain: CLIB 382, CLIB 556 and CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 81
FT /note="F -> L (in strain: CLIB 219, CLIB 382, CLIB 413,
FT CLIB 556 and CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 92
FT /note="R -> Q (in strain: CLIB 382, CLIB 556 and CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 99
FT /note="M -> G (in strain: CLIB 413)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 100
FT /note="V -> L (in strain: CLIB 382, CLIB 413, CLIB 556 and
FT CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 106
FT /note="S -> L (in strain: CLIB 382, CLIB 556 and CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 119
FT /note="K -> N (in strain: CLIB 382 haplotype Ha2)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 203
FT /note="S -> P (in strain: CLIB 382, CLIB 556, CLIB 630, K1
FT and R13 haplotype Ha2)"
FT /evidence="ECO:0000269|PubMed:15087486"
SQ SEQUENCE 240 AA; 27571 MW; D7D0024F934B3453 CRC64;
MQPYLKKNTH ATDDPKASPL KEGSPDNPES PLISADIVLP EDEFASYQSY LLYEIVRAKY
IMINFLLFVV TILATLTDIW FSGVLSPAMV IRICLGGSMV VLQIWSFSRP ISNETFRTKL
LLEVITHRPS IAGKEWKTIT YNMNQYLFKA GLWKTPYHFF CEHQCYEFFK DLIKGKYPDV
QWDTANTQPF ISVPENQAAT QNSDVEPTVK WCLFKAAEIQ AHAVREYWQS QYPDVGIPAI
