ID   CATD_BACSU              Reviewed;         134 AA.
AC   P54720;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Putative oxidoreductase CatD;
DE            EC=1.-.-.-;
GN   Name=catD; Synonyms=yfiD; OrderedLocusNames=BSU08230;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8704981; DOI=10.1099/13500872-142-6-1417;
RA   Yamamoto H., Uchiyama S., Fajar A.N., Ogasawara N., Sekiguchi J.;
RT   "Determination of a 12 kb nucleotide sequence around the 76 degrees region
RT   of the Bacillus subtilis chromosome.";
RL   Microbiology 142:1417-1421(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=168;
RX   PubMed=16872404; DOI=10.1111/j.1462-2920.2006.01034.x;
RA   Tam le T., Eymann C., Albrecht D., Sietmann R., Schauer F., Hecker M.,
RA   Antelmann H.;
RT   "Differential gene expression in response to phenol and catechol reveals
RT   different metabolic activities for the degradation of aromatic compounds in
RT   Bacillus subtilis.";
RL   Environ. Microbiol. 8:1408-1427(2006).
RN   [4]
RP   INDUCTION, AND NOMENCLATURE.
RC   STRAIN=168;
RX   PubMed=17407181; DOI=10.1002/pmic.200700008;
RA   Nguyen V.D., Wolf C., Maeder U., Lalk M., Langer P., Lindequist U.,
RA   Hecker M., Antelmann H.;
RT   "Transcriptome and proteome analyses in response to 2-methylhydroquinone
RT   and 6-brom-2-vinyl-chroman-4-on reveal different degradation systems
RT   involved in the catabolism of aromatic compounds in Bacillus subtilis.";
RL   Proteomics 7:1391-1408(2007).
CC   -!- FUNCTION: Essential for growth and viability in the presence of
CC       catechol and probably involved in the detoxification of catechol.
CC       {ECO:0000269|PubMed:16872404}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Strongly induced by catechol, less strongly by 2-
CC       methylhydroquinone (2-MHQ) but only weakly by chromanon (6-brom-2-
CC       vinyl-chroman-4-on). {ECO:0000269|PubMed:16872404,
CC       ECO:0000269|PubMed:17407181}.
CC   -!- SIMILARITY: Belongs to the DoxX family. {ECO:0000305}.
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DR   EMBL; D50543; BAA09108.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12652.1; -; Genomic_DNA.
DR   PIR; G69802; G69802.
DR   RefSeq; NP_388704.1; NC_000964.3.
DR   RefSeq; WP_003244204.1; NZ_JNCM01000032.1.
DR   AlphaFoldDB; P54720; -.
DR   SMR; P54720; -.
DR   STRING; 224308.BSU08230; -.
DR   PaxDb; P54720; -.
DR   EnsemblBacteria; CAB12652; CAB12652; BSU_08230.
DR   GeneID; 939204; -.
DR   KEGG; bsu:BSU08230; -.
DR   PATRIC; fig|224308.179.peg.889; -.
DR   eggNOG; COG2259; Bacteria.
DR   InParanoid; P54720; -.
DR   OMA; YVIATIE; -.
DR   PhylomeDB; P54720; -.
DR   BioCyc; BSUB:BSU08230-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR   InterPro; IPR032808; DoxX.
DR   Pfam; PF07681; DoxX; 1.
PE   2: Evidence at transcript level;
KW   Aromatic hydrocarbons catabolism; Cell membrane; Detoxification; Membrane;
KW   Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..134
FT                   /note="Putative oxidoreductase CatD"
FT                   /id="PRO_0000049524"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   134 AA;  14419 MW;  6BCF8F7EDAB67117 CRC64;
     MNKSFEIGTL LLRVITGIIF FVHGLSKFQG MEGTIQFFGS IGLPSFMAYV IAAIELIGGV
     LVFFGLATRI VGVLFALTLI GAIITVKLKA PFMGNAEFDY LLLLTSIHLA LTGSRFLALD
     PFVFKGKKNG NVSA