YAJC_HELPY
ID YAJC_HELPY Reviewed; 127 AA.
AC O26075;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Sec translocon accessory complex subunit YajC;
GN Name=yajC; OrderedLocusNames=HP_1551;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein
CC secretase/insertase is a supercomplex required for protein secretion,
CC insertion of proteins into membranes, and assembly of membrane protein
CC complexes. While the SecYEG complex is essential for assembly of a
CC number of proteins and complexes, the SecDF-YajC-YidC subcomplex
CC facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBUNIT: Part of the SecDF-YidC-YajC translocase complex. The SecDF-
CC YidC-YajC translocase forms a supercomplex with SecYEG, called the
CC holo-translocon (HTL). {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0ADZ7}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SIMILARITY: Belongs to the YajC family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08591.1; -; Genomic_DNA.
DR PIR; G64713; G64713.
DR RefSeq; NP_208342.1; NC_000915.1.
DR RefSeq; WP_000529779.1; NC_018939.1.
DR AlphaFoldDB; O26075; -.
DR SMR; O26075; -.
DR STRING; 85962.C694_08035; -.
DR PaxDb; O26075; -.
DR EnsemblBacteria; AAD08591; AAD08591; HP_1551.
DR KEGG; hpy:HP_1551; -.
DR PATRIC; fig|85962.47.peg.1666; -.
DR eggNOG; COG1862; Bacteria.
DR OMA; AKKHKEM; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003849; Preprotein_translocase_YajC.
DR PANTHER; PTHR33909; PTHR33909; 1.
DR Pfam; PF02699; YajC; 1.
DR PRINTS; PR01853; YAJCTRNLCASE.
DR SMART; SM01323; YajC; 1.
DR TIGRFAMs; TIGR00739; yajC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..127
FT /note="Sec translocon accessory complex subunit YajC"
FT /id="PRO_0000097032"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 127 AA; 14392 MW; F559293A04D5EE40 CRC64;
MGQIKDILTT LLPLVVLFLI FYFLIVRPQR QQQKKHKEMI ESLTKGDKIV TQGGLIVEVL
KAEANFFSVK LNDDTTAKLS KNYVAFKLDE LDQFGLAEPI VIQQGREEIS AKLSGAKTLK
QRQITTE