YAJC_MYCBO
ID YAJC_MYCBO Reviewed; 115 AA.
AC P65026; A0A1R3Y1W0; Q50633; X2BLD3;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Sec translocon accessory complex subunit YajC;
GN Name=yajC; OrderedLocusNames=BQ2027_MB2619C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein
CC secretase/insertase is a supercomplex required for protein secretion,
CC insertion of proteins into membranes, and assembly of membrane protein
CC complexes. While the SecYEG complex is essential for assembly of a
CC number of proteins and complexes, the SecDF-YajC-YidC subcomplex
CC facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBUNIT: Part of the SecDF-YidC-YajC translocase complex. The SecDF-
CC YidC-YajC translocase forms a supercomplex with SecYEG, called the
CC holo-translocon (HTL). {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the YajC family. {ECO:0000305}.
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DR EMBL; LT708304; SIU01237.1; -; Genomic_DNA.
DR RefSeq; NP_856265.1; NC_002945.3.
DR RefSeq; WP_003413391.1; NC_002945.4.
DR AlphaFoldDB; P65026; -.
DR SMR; P65026; -.
DR EnsemblBacteria; SIU01237; SIU01237; BQ2027_MB2619C.
DR GeneID; 45426590; -.
DR PATRIC; fig|233413.5.peg.2880; -.
DR OMA; GVMYFMM; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003849; Preprotein_translocase_YajC.
DR PANTHER; PTHR33909; PTHR33909; 1.
DR Pfam; PF02699; YajC; 1.
DR SMART; SM01323; YajC; 1.
DR TIGRFAMs; TIGR00739; yajC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Protein transport; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..115
FT /note="Sec translocon accessory complex subunit YajC"
FT /id="PRO_0000014140"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 96..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 115 AA; 12967 MW; 5DACBA453C1F7C12 CRC64;
MESFVLFLPF LLIMGGFMYF ASRRQRRAMQ ATIDLHDSLQ PGERVHTTSG LEATIVAIAD
DTIDLEIAPG VVTTWMKLAI RDRILPDDDI DEELNEDLDK DVDDVAGERR VTNDS
