YAJC_MYCLE
ID YAJC_MYCLE Reviewed; 114 AA.
AC Q49647;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Sec translocon accessory complex subunit YajC;
GN Name=yajC; OrderedLocusNames=ML0486; ORFNames=B1177_C3_235, MLCB1259.04;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Smith D.R., Robison K.;
RL Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein
CC secretase/insertase is a supercomplex required for protein secretion,
CC insertion of proteins into membranes, and assembly of membrane protein
CC complexes. While the SecYEG complex is essential for assembly of a
CC number of proteins and complexes, the SecDF-YajC-YidC subcomplex
CC facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBUNIT: Part of the SecDF-YidC-YajC translocase complex. The SecDF-
CC YidC-YajC translocase forms a supercomplex with SecYEG, called the
CC holo-translocon (HTL). {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the YajC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA17099.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U00011; AAA17099.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL023591; CAA19079.1; -; Genomic_DNA.
DR EMBL; AL583918; CAC29994.1; -; Genomic_DNA.
DR PIR; F86969; F86969.
DR PIR; S72735; S72735.
DR RefSeq; NP_301426.1; NC_002677.1.
DR RefSeq; WP_010907750.1; NC_002677.1.
DR AlphaFoldDB; Q49647; -.
DR SMR; Q49647; -.
DR STRING; 272631.ML0486; -.
DR EnsemblBacteria; CAC29994; CAC29994; CAC29994.
DR KEGG; mle:ML0486; -.
DR PATRIC; fig|272631.5.peg.850; -.
DR Leproma; ML0486; -.
DR eggNOG; COG1862; Bacteria.
DR HOGENOM; CLU_116157_4_2_11; -.
DR OMA; GVMYFMM; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003849; Preprotein_translocase_YajC.
DR PANTHER; PTHR33909; PTHR33909; 1.
DR Pfam; PF02699; YajC; 1.
DR SMART; SM01323; YajC; 1.
DR TIGRFAMs; TIGR00739; yajC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Protein transport; Reference proteome;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..114
FT /note="Sec translocon accessory complex subunit YajC"
FT /id="PRO_0000014141"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 114 AA; 12749 MW; 7083FED889F38839 CRC64;
MESLVLLLLF LLIMGGFMFF ASRRQRRSMQ ATIDLYNSLQ PGDRVNTTSG LQATIIVVGD
DTVDLEIAPG VVTTWMKLAI RDRILPDDAY MDEHEAEPGD FVYCDELEES DGSS
