ID   YAJC_MYCTU              Reviewed;         115 AA.
AC   P9WL75; L0TBQ2; P65025; Q50633;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Sec translocon accessory complex subunit YajC;
GN   Name=yajC; OrderedLocusNames=Rv2588c; ORFNames=MTCY227.13;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein
CC       secretase/insertase is a supercomplex required for protein secretion,
CC       insertion of proteins into membranes, and assembly of membrane protein
CC       complexes. While the SecYEG complex is essential for assembly of a
CC       number of proteins and complexes, the SecDF-YajC-YidC subcomplex
CC       facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}.
CC   -!- SUBUNIT: Part of the SecDF-YidC-YajC translocase complex. The SecDF-
CC       YidC-YajC translocase forms a supercomplex with SecYEG, called the
CC       holo-translocon (HTL). {ECO:0000250|UniProtKB:P0ADZ7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the YajC family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45384.1; -; Genomic_DNA.
DR   PIR; C70726; C70726.
DR   RefSeq; NP_217104.1; NC_000962.3.
DR   RefSeq; WP_003413391.1; NZ_NVQJ01000023.1.
DR   AlphaFoldDB; P9WL75; -.
DR   SMR; P9WL75; -.
DR   STRING; 83332.Rv2588c; -.
DR   PaxDb; P9WL75; -.
DR   DNASU; 887346; -.
DR   GeneID; 45426590; -.
DR   GeneID; 887346; -.
DR   KEGG; mtu:Rv2588c; -.
DR   TubercuList; Rv2588c; -.
DR   eggNOG; COG1862; Bacteria.
DR   OMA; GVMYFMM; -.
DR   PhylomeDB; P9WL75; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003849; Preprotein_translocase_YajC.
DR   PANTHER; PTHR33909; PTHR33909; 1.
DR   Pfam; PF02699; YajC; 1.
DR   SMART; SM01323; YajC; 1.
DR   TIGRFAMs; TIGR00739; yajC; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..115
FT                   /note="Sec translocon accessory complex subunit YajC"
FT                   /id="PRO_0000014139"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          96..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  12967 MW;  5DACBA453C1F7C12 CRC64;
     MESFVLFLPF LLIMGGFMYF ASRRQRRAMQ ATIDLHDSLQ PGERVHTTSG LEATIVAIAD
     DTIDLEIAPG VVTTWMKLAI RDRILPDDDI DEELNEDLDK DVDDVAGERR VTNDS