YAJC_SHIFL
ID YAJC_SHIFL Reviewed; 110 AA.
AC P0AE00; P19677;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Sec translocon accessory complex subunit YajC;
GN Name=yajC; OrderedLocusNames=SF0344, S0352;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=YSH6000 / Serotype 2a;
RX PubMed=8045893; DOI=10.1128/jb.176.15.4627-4634.1994;
RA Durand J.M., Okada N., Tobe T., Watarai M., Fukuda I., Suzuki T.,
RA Nakata N., Komatsu K., Yoshikawa M., Sasakawa C.;
RT "vacC, a virulence-associated chromosomal locus of Shigella flexneri, is
RT homologous to tgt, a gene encoding tRNA-guanine transglycosylase (Tgt) of
RT Escherichia coli K-12.";
RL J. Bacteriol. 176:4627-4634(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein
CC secretase/insertase is a supercomplex required for protein secretion,
CC insertion of proteins into membranes, and assembly of membrane protein
CC complexes. While the SecYEG complex is essential for assembly of a
CC number of proteins and complexes, the SecDF-YajC-YidC subcomplex
CC facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBUNIT: Part of the SecDF-YidC-YajC translocase complex. The SecDF-
CC YidC-YajC translocase forms a supercomplex with SecYEG, called the
CC holo-translocon (HTL). {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0ADZ7}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P0ADZ7}.
CC -!- SIMILARITY: Belongs to the YajC family. {ECO:0000305}.
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DR EMBL; D26469; BAA05483.1; -; Genomic_DNA.
DR EMBL; AE005674; AAN42002.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP15879.1; -; Genomic_DNA.
DR RefSeq; NP_706295.1; NC_004337.2.
DR RefSeq; WP_000007629.1; NZ_WPGW01000023.1.
DR AlphaFoldDB; P0AE00; -.
DR SMR; P0AE00; -.
DR STRING; 198214.SF0344; -.
DR PRIDE; P0AE00; -.
DR EnsemblBacteria; AAN42002; AAN42002; SF0344.
DR EnsemblBacteria; AAP15879; AAP15879; S0352.
DR GeneID; 1027685; -.
DR GeneID; 67416520; -.
DR KEGG; sfl:SF0344; -.
DR KEGG; sfx:S0352; -.
DR PATRIC; fig|198214.7.peg.395; -.
DR HOGENOM; CLU_116157_2_1_6; -.
DR OMA; GMEMIIM; -.
DR OrthoDB; 2082059at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003849; Preprotein_translocase_YajC.
DR PANTHER; PTHR33909; PTHR33909; 1.
DR Pfam; PF02699; YajC; 1.
DR PRINTS; PR01853; YAJCTRNLCASE.
DR SMART; SM01323; YajC; 1.
DR TIGRFAMs; TIGR00739; yajC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..110
FT /note="Sec translocon accessory complex subunit YajC"
FT /id="PRO_0000097016"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 110 AA; 11887 MW; 8E90AF51F0205306 CRC64;
MSFFISDAVA ATGAPAQGSP MSLILMLVVF GLIFYFMILR PQQKRTKEHK KLMDSIAKGD
EVLTNGGLVG RVTKVAENGY IAIALNDTTE VVIKRDFVAA VLPKGTMKAL
