ID   YAM3_SCHPO              Reviewed;         382 AA.
AC   Q10058;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Putative oxidoreductase C1F5.03c;
DE            EC=1.-.-.-;
GN   ORFNames=SPAC1F5.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Putative oxidoreductase that negatively regulates the
CC       retrieval of cargo from late endosomes to the Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TDA3 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA92231.1; -; Genomic_DNA.
DR   PIR; T38092; T38092.
DR   RefSeq; NP_592870.1; NM_001018270.2.
DR   AlphaFoldDB; Q10058; -.
DR   SMR; Q10058; -.
DR   BioGRID; 277973; 20.
DR   STRING; 4896.SPAC1F5.03c.1; -.
DR   MaxQB; Q10058; -.
DR   PaxDb; Q10058; -.
DR   EnsemblFungi; SPAC1F5.03c.1; SPAC1F5.03c.1:pep; SPAC1F5.03c.
DR   GeneID; 2541471; -.
DR   KEGG; spo:SPAC1F5.03c; -.
DR   PomBase; SPAC1F5.03c; -.
DR   VEuPathDB; FungiDB:SPAC1F5.03c; -.
DR   eggNOG; KOG2852; Eukaryota.
DR   HOGENOM; CLU_007884_14_0_1; -.
DR   InParanoid; Q10058; -.
DR   OMA; MAEMIFE; -.
DR   PhylomeDB; Q10058; -.
DR   PRO; PR:Q10058; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; ISO:PomBase.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:PomBase.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Membrane; Oxidoreductase; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..382
FT                   /note="Putative oxidoreductase C1F5.03c"
FT                   /id="PRO_0000116443"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   382 AA;  41502 MW;  C0AF06F5534C3710 CRC64;
     MSNSRNIVIV GGGITGVSCL YFLAHHPSFN RDRDTITLFE SAGIASAASG KASGFLSLEW
     HGPSTSSLAA LSYNLHKELS DQYDGVNKWG YRALDTWSIK ADENCQQPDK LPEGIEWIAP
     SIVENVTRLG NKKNSGQVHP YKFCHAIYEE ASKVANVTLV KGHVLSVDEN EVEYRLIGDD
     YAPDEEEEIT SAEELHTIHS MEATHIIVAA GPWTPQLIPN LRISGARIHS ITIDLPIKLN
     GNAVFSEITY KDGTIAAPEF YAREDELYVC GEFDDEPLPE LSSDTKVDQD KCALIKQCAN
     HFHQIIRDSP VKVRQACYLP ISNATGAPVI GKIGSSIYVA AAHGCWGITL GPGTGKVLSE
     LILDGAVTSA NIDLLDPEGS LE