ID   YAML_STRLM              Reviewed;         351 AA.
AC   P23823;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator in aml 5'region;
DE   AltName: Full=ORF-S1;
OS   Streptomyces limosus (Streptomyces albidoflavus).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=1947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   van Wezel G.P., White J., Young P., Postma P., Bibb M.J.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 325-351.
RX   PubMed=3500166; DOI=10.1128/jb.169.12.5745-5754.1987;
RA   Long C.M., Virolle M.-J., Chang S.-Y., Chang S., Bibb M.J.;
RT   "Alpha-amylase gene of Streptomyces limosus: nucleotide sequence,
RT   expression motifs, and amino acid sequence homology to mammalian and
RT   invertebrate alpha-amylases.";
RL   J. Bacteriol. 169:5745-5754(1987).
CC   -!- FUNCTION: Putative sugar-binding regulatory protein for the alpha-
CC       amylase gene.
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DR   EMBL; Y08304; CAA69613.1; -; Genomic_DNA.
DR   EMBL; M18244; AAA88553.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..351
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   in aml 5'region"
FT                   /id="PRO_0000108012"
FT   DOMAIN          14..69
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        16..35
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   351 AA;  37595 MW;  23D378640ABA716B CRC64;
     MTLPAPRDGS PAVPRLADIA AQAQVSEATA SRVLNGRPAS RXSTRQRVLA ALDLLGYERP
     TRLRRRSAGL IGLVTPELTN PIFPAFAQVV EQALAGYGYT PVLCTQIPGG ATEDELVEQL
     EERGVNGIVF LSGLHADTTA DPRRYARLTE RGVPFVLING YNERIRAPFV SPDDRSAVRM
     AVRHLADLGH RRIGLAVGPD RYVPSRRKAE GFADALAEIL GTPRDQAEQH VRRTLFSVEG
     GHAAAGSLLE QGCTGLVCGS DLMALGAVRA ARERGLDVPA DLSVVGFDDS QLVAFTDPPL
     TTVRQPVHAM ATAAVGALLE EIAHQTVQRT EFVFQPELVV RGSTAQWVPG G