YAOL_ARATH
ID YAOL_ARATH Reviewed; 479 AA.
AC Q3MKM6; O49554;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=U3 snoRNP-associated protein-like EMB2271 {ECO:0000305};
DE AltName: Full=Protein EMBRYO DEFECTIVE 2271 {ECO:0000305};
DE AltName: Full=Protein YAO-like {ECO:0000305};
GN Name=EMB2271 {ECO:0000312|EMBL:AEE84406.1};
GN OrderedLocusNames=At4g21130 {ECO:0000312|Araport:AT4G21130};
GN ORFNames=F7J7.70 {ECO:0000312|EMBL:CAA17532.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=16054306; DOI=10.1016/j.gene.2005.05.022;
RA Urbanek P., Paces J., Paces V.;
RT "An approach towards experimental cDNA sequence determination of predicted
RT genes: an example from Arabidopsis U3-55k homologues.";
RL Gene 358:67-72(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20699009; DOI=10.1186/1471-2229-10-169;
RA Li H.J., Liu N.Y., Shi D.Q., Liu J., Yang W.C.;
RT "YAO is a nucleolar WD40-repeat protein critical for embryogenesis and
RT gametogenesis in Arabidopsis.";
RL BMC Plant Biol. 10:169-169(2010).
CC -!- FUNCTION: Component of a nucleolar small nuclear ribonucleoprotein
CC particle (snoRNP) thought to participate in the processing and
CC modification of pre-ribosomal RNA (By similarity). Essential for
CC embryogenesis (By similarity). May function during late embryogenesis
CC (PubMed:20699009). {ECO:0000250|UniProtKB:O43818,
CC ECO:0000250|UniProtKB:Q9M0V4, ECO:0000305|PubMed:20699009}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9M0V4}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality.
CC {ECO:0000305|PubMed:20699009}.
CC -!- SIMILARITY: Belongs to the WD repeat RRP9 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA17532.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79113.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY874865; AAY21208.1; -; mRNA.
DR EMBL; AL021960; CAA17532.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161554; CAB79113.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE84406.1; -; Genomic_DNA.
DR PIR; T04944; T04944.
DR RefSeq; NP_193845.2; NM_118232.2.
DR AlphaFoldDB; Q3MKM6; -.
DR SMR; Q3MKM6; -.
DR STRING; 3702.AT4G21130.1; -.
DR PaxDb; Q3MKM6; -.
DR PRIDE; Q3MKM6; -.
DR ProteomicsDB; 228662; -.
DR EnsemblPlants; AT4G21130.1; AT4G21130.1; AT4G21130.
DR GeneID; 827861; -.
DR Gramene; AT4G21130.1; AT4G21130.1; AT4G21130.
DR KEGG; ath:AT4G21130; -.
DR Araport; AT4G21130; -.
DR TAIR; locus:2127408; AT4G21130.
DR eggNOG; KOG0299; Eukaryota.
DR HOGENOM; CLU_014017_1_1_1; -.
DR InParanoid; Q3MKM6; -.
DR OMA; WAIENSS; -.
DR OrthoDB; 948159at2759; -.
DR PhylomeDB; Q3MKM6; -.
DR PRO; PR:Q3MKM6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q3MKM6; baseline and differential.
DR Genevisible; Q3MKM6; AT.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; ISS:TAIR.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR039241; Rrp9-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19865; PTHR19865; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW rRNA processing; WD repeat.
FT CHAIN 1..479
FT /note="U3 snoRNP-associated protein-like EMB2271"
FT /id="PRO_0000433091"
FT REPEAT 143..182
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 204..243
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 246..285
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 288..326
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 328..366
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 386..425
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 431..471
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..57
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 53582 MW; 5A3F4C14FF461B12 CRC64;
MKLEKKKGIG AKRRGKKSSI DHDPFLEEET EKRRKFNYDD DDDIESVESE EEGKVGEEVE
DEFAHETVGE KRKRLAEDTL NRIEEAKQRE HEEDNEEDDD FRDSLVAKTL MQEQLEKSGR
VRRANALRVQ DLQSSDKFRV IVKHQHSVTG VALSDDDSRG FSVSKDGTIL HWDVSSGKSD
EYKWPSDEVL KSHGLKFQES WYTRHNKQSL ALAVSSDGRY LATGGVDCHV HLWDIRTREH
VQAFTGHCGI VSSLCFREGT AELFSGSYDG TLSIWNAEHR TYIESCFGHQ SELLSIDALG
RERVLSVGRD RTMQLYKVPE STRLIYRASE SNFECCCFVN SDEFLSGSDN GSIALWSILK
KKPVFIVNNA HHVIADHDSV NHNCTPACSW VSSVAVCRGS ELAASGAGNG CVRLWGVESG
SSAIQPLYEL PLPGFVNSLA FAKSGRFLIA GVGQEPRLGR WGCLKSAQNG VAIHPLRLS
