ID   YAP1B_XENLA             Reviewed;         335 AA.
AC   Q32NJ6;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Transcriptional coactivator YAP1-B;
DE            Short=Yes-associated protein 1-B;
DE   AltName: Full=Protein yorkie homolog-B;
DE   AltName: Full=Yes-associated protein YAP65 homolog B;
GN   Name=yap1-b {ECO:0000305};
GN   Synonyms=yap1 {ECO:0000312|Xenbase:XB-GENE-952397};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAI08592.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator which can act both as a coactivator
CC       and a corepressor and is the critical downstream regulatory target in
CC       the Hippo signaling pathway that plays a pivotal role in organ size
CC       control and tumor suppression by restricting proliferation and
CC       promoting apoptosis (By similarity). Plays a key role in tissue tension
CC       and 3D tissue shape by regulating cortical actomyosin network formation
CC       (By similarity). {ECO:0000250|UniProtKB:H2LBU8,
CC       ECO:0000250|UniProtKB:P46937}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P46937}. Nucleus
CC       {ECO:0000250|UniProtKB:P46937}. Note=Both phosphorylation and cell
CC       density can regulate its subcellular localization. Phosphorylation
CC       sequesters it in the cytoplasm by inhibiting its translocation into the
CC       nucleus. At low density, predominantly nuclear and is translocated to
CC       the cytoplasm at high density. {ECO:0000250|UniProtKB:P46937}.
CC   -!- PTM: Phosphorylated by lats1 and lats2; leading to cytoplasmic
CC       translocation and inactivation. {ECO:0000250|UniProtKB:P46937}.
CC   -!- SIMILARITY: Belongs to the YAP1 family. {ECO:0000305}.
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DR   EMBL; BC108591; AAI08592.1; -; mRNA.
DR   RefSeq; NP_001167495.1; NM_001174024.1.
DR   AlphaFoldDB; Q32NJ6; -.
DR   SMR; Q32NJ6; -.
DR   DNASU; 100381098; -.
DR   GeneID; 100381098; -.
DR   KEGG; xla:100381098; -.
DR   CTD; 100381098; -.
DR   Xenbase; XB-GENE-952397; yap1.S.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 100381098; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..335
FT                   /note="Transcriptional coactivator YAP1-B"
FT                   /id="PRO_0000433908"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          137..335
FT                   /note="Transactivation domain"
FT                   /evidence="ECO:0000250|UniProtKB:P46937"
FT   COILED          145..173
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        114..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         30
FT                   /note="Phosphoserine; by LATS1 and LATS2"
FT                   /evidence="ECO:0000250|UniProtKB:P46937"
SQ   SEQUENCE   335 AA;  37120 MW;  CCE7A8815409D811 CRC64;
     MEPGSQQQPS APGQQPPPVG HQIVHVRTDS ETDLETLFNA VMNPKNANVP QTLPMRMRKL
     PDSFFKQPEP KSHSRHVDQT TTWQDPRKAM LSQINITAPT SPPVQQNIMT PTAMNQQRLS
     QSAPVKSPPA LQPQSPPSGV LGSGGNQQMR LQQLQMEKER LRLKHQELLR QVRPQELALR
     SQIPPMEQDS GPPNPVCSSG ISQELRTMTM NSSDPFLNSG TYHSRDESTD SGLSMSSYSV
     PRTPDDFLNS VDEMDTGEAI TQSTIPTQQN RFPDYLETLP GTNVDLGTLE GEAMNVEGEE
     LMPSLQEALS SDILNDMETV LAATKLDKES FLTWL