YAP5_YEAST
ID YAP5_YEAST Reviewed; 245 AA.
AC P40574; D6VVU8;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=AP-1-like transcription factor YAP5;
GN Name=YAP5; OrderedLocusNames=YIR018W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 28383 / FL100 / VTT C-80102;
RX PubMed=8665859; DOI=10.1002/j.1460-2075.1996.tb00609.x;
RA Kuras L., Cherest H., Surdin-Kerjan Y., Thomas D.;
RT "A heteromeric complex containing the centromere binding factor 1 and two
RT basic leucine zipper factors, Met4 and Met28, mediates the transcription
RT activation of yeast sulfur metabolism.";
RL EMBO J. 15:2519-2529(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION, AND ISOLATION OF YAP FAMILY PROTEINS.
RX PubMed=9372930; DOI=10.1128/mcb.17.12.6982;
RA Fernandes L., Rodrigues-Pousada C., Struhl K.;
RT "Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae
RT with distinct biological functions.";
RL Mol. Cell. Biol. 17:6982-6993(1997).
RN [6]
RP FUNCTION, AND CELL CYCLE ACTIVATION.
RX PubMed=12464632; DOI=10.1101/gad.1039602;
RA Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S.,
RA Gerstein M., Snyder M.;
RT "Complex transcriptional circuitry at the G1/S transition in Saccharomyces
RT cerevisiae.";
RL Genes Dev. 16:3017-3033(2002).
RN [7]
RP FUNCTION, AND REGULATORY TRANSCRIPTION MODULES.
RX PubMed=14555958; DOI=10.1038/nbt890;
RA Bar-Joseph Z., Gerber G.K., Lee T.I., Rinaldi N.J., Yoo J.Y., Robert F.,
RA Gordon D.B., Fraenkel E., Jaakkola T.S., Young R.A., Gifford D.K.;
RT "Computational discovery of gene modules and regulatory networks.";
RL Nat. Biotechnol. 21:1337-1342(2003).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [9]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Transcription activator involved in the regulation of genes
CC expressed in response to environmental changes and metabolic
CC requirements. According to genome-wide promoter binding and gene
CC expression studies it is a coregulator for the expression of ribosomal
CC genes, while its own expression is induced by the cell cycle specific
CC activator SBF (SWI4-SWI6). {ECO:0000269|PubMed:12464632,
CC ECO:0000269|PubMed:14555958, ECO:0000269|PubMed:9372930}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins
CC (YAP1 to YAP8), which all seem to be transcription activators of the
CC environmental stress response and metabolism control pathways and to
CC have similar but not identical DNA binding specificities.
CC -!- MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the bZIP family. YAP subfamily. {ECO:0000305}.
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DR EMBL; U17015; AAC49426.1; -; Genomic_DNA.
DR EMBL; Z37996; CAA86089.1; -; Genomic_DNA.
DR EMBL; AY558238; AAS56564.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08564.1; -; Genomic_DNA.
DR PIR; S48363; S48363.
DR RefSeq; NP_012283.1; NM_001179540.1.
DR AlphaFoldDB; P40574; -.
DR SMR; P40574; -.
DR BioGRID; 35010; 44.
DR DIP; DIP-2994N; -.
DR IntAct; P40574; 5.
DR MINT; P40574; -.
DR STRING; 4932.YIR018W; -.
DR PaxDb; P40574; -.
DR PRIDE; P40574; -.
DR EnsemblFungi; YIR018W_mRNA; YIR018W; YIR018W.
DR GeneID; 854835; -.
DR KEGG; sce:YIR018W; -.
DR SGD; S000001457; YAP5.
DR VEuPathDB; FungiDB:YIR018W; -.
DR eggNOG; ENOG502QUE5; Eukaryota.
DR HOGENOM; CLU_963771_0_0_1; -.
DR InParanoid; P40574; -.
DR OMA; CICSELE; -.
DR BioCyc; YEAST:G3O-31438-MON; -.
DR PRO; PR:P40574; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40574; protein.
DR GO; GO:0000785; C:chromatin; IDA:SGD.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR GO; GO:0010723; P:positive regulation of transcription from RNA polymerase II promoter in response to iron; IMP:SGD.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..245
FT /note="AP-1-like transcription factor YAP5"
FT /id="PRO_0000076525"
FT DOMAIN 58..121
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 34..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..82
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 86..114
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 45..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 173
FT /note="P -> S (in Ref. 1; AAC49426)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 28386 MW; 02F78E1963982E0D CRC64;
MALPLIKPKE SEESHLALLS KIHVSKNWKL PPRLPHRAAQ RRKRVHRLHE DYETEENDEE
LQKKKRQNRD AQRAYRERKN NKLQVLEETI ESLSKVVKNY ETKLNRLQNE LQAKESENHA
LKQKLETLTL KQASVPAQDP ILQNLIENFK PMKAIPIKYN TAIKRHQHST ELPSSVKCGF
CNDNTTCVCK ELETDHRKSD DGVATEQKDM SMPHAECNNK DNPNGLCSNC TNIDKSCIDI
RSIIH